about
The glyoxalase system: new developments towards functional characterization of a metabolic pathway fundamental to biological lifeOverexpression of glyoxalase-I in bovine endothelial cells inhibits intracellular advanced glycation endproduct formation and prevents hyperglycemia-induced increases in macromolecular endocytosisGlycation of LDL by methylglyoxal increases arterial atherogenicity: a possible contributor to increased risk of cardiovascular disease in diabetesGLO1-A novel amplified gene in human cancerHigh prevalence of low plasma thiamine concentration in diabetes linked to a marker of vascular diseaseDicarbonyl stress in cell and tissue dysfunction contributing to ageing and diseasePrevention of incipient diabetic nephropathy by high-dose thiamine and benfotiamineMethylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathyFluorimetric assay of D-lactateHigh glucose increases angiopoietin-2 transcription in microvascular endothelial cells through methylglyoxal modification of mSin3AFrequency Modulated Translocational Oscillations of Nrf2 Mediate the Antioxidant Response Element Cytoprotective Transcriptional Response.Antitumour activity of sphingoid base adducts of phenethyl isothiocyanate.Increased glycation and oxidative damage to apolipoprotein B100 of LDL cholesterol in patients with type 2 diabetes and effect of metformin.Isothiocyanates: mechanism of cancer chemopreventive action.Disturbance of B-vitamin status in people with type 2 diabetes in Indonesia--link to renal status, glycemic control and vascular inflammation.Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetesArginine-directed glycation and decreased HDL plasma concentration and functionalityThe formation of methylglyoxal from triose phosphates. Investigation using a specific assay for methylglyoxal.Differential effects of glyoxalase 1 overexpression on diabetic atherosclerosis and renal dysfunction in streptozotocin-treated, apolipoprotein E-deficient mice.Synthesis and secretion of tumour necrosis factor-alpha by human monocytic THP-1 cells and chemotaxis induced by human serum albumin derivatives modified with methylglyoxal and glucose-derived advanced glycation endproducts.Unease on the role of glyoxalase 1 in high-anxiety-related behaviour.Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress.Glucose-induced down regulation of thiamine transporters in the kidney proximal tubular epithelium produces thiamine insufficiency in diabetes.Effect of storage, processing and cooking on glucosinolate content of Brassica vegetables.Detection of oxidized and glycated proteins in clinical samples using mass spectrometry--a user's perspective.Biomarkers of early stage osteoarthritis, rheumatoid arthritis and musculoskeletal health.Increased DNA dicarbonyl glycation and oxidation markers in patients with type 2 diabetes and link to diabetic nephropathy.Use of aminoguanidine (Pimagedine) to prevent the formation of advanced glycation endproducts.Unraveling the biological roles of reactive oxygen speciesAdvanced glycation end products in renal failure.Dietary AGEs and ALEs and risk to human health by their interaction with the receptor for advanced glycation endproducts (RAGE)--an introduction.Reversal of hyperglycemia-induced angiogenesis deficit of human endothelial cells by overexpression of glyoxalase 1 in vitroProtein and nucleotide damage by glyoxal and methylglyoxal in physiological systems--role in ageing and disease.Assay of 3-nitrotyrosine in tissues and body fluids by liquid chromatography with tandem mass spectrometric detection.Dicarbonyls and glyoxalase in disease mechanisms and clinical therapeuticsProtein oxidation, nitration and glycation biomarkers for early-stage diagnosis of osteoarthritis of the knee and typing and progression of arthritic disease.Advanced glycation end products in extracellular matrix proteins contribute to the failure of sensory nerve regeneration in diabetes.The role of EUTox in uremic toxin research.Highlights and hotspots of protein glycation in end-stage renal disease.Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome.
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Paul J Thornalley
@ast
Paul J Thornalley
@en
Paul J Thornalley
@es
Paul J Thornalley
@nl
type
label
Paul J Thornalley
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Paul J Thornalley
@en
Paul J Thornalley
@es
Paul J Thornalley
@nl
prefLabel
Paul J Thornalley
@ast
Paul J Thornalley
@en
Paul J Thornalley
@es
Paul J Thornalley
@nl
P106
P1153
7005307338
P21
P31
P496
0000-0001-7659-443X