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The Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III activity is inhibited by phosphorylation on a single threonine residueX-Ray Crystal Structure of Mycobacterium tuberculosis β-Ketoacyl Acyl Carrier Protein Synthase II (mtKasB)The structure of Mycobacterium tuberculosis MPT51 (FbpC1) defines a new family of non-catalytic alpha/beta hydrolasesStructure ofMycobacterium tuberculosismtFabD, a malonyl-CoA:acyl carrier protein transacylase (MCAT)The Fatty Acid Biosynthesis Enzyme FabI Plays a Key Role in the Development of Liver-Stage Malarial ParasitesDynamic and structural characterization of a bacterial FHA protein reveals a new autoinhibition mechanismThe Mycobacterium tuberculosis Ser/Thr Kinase Substrate Rv2175c Is a DNA-binding Protein Regulated by PhosphorylationPhosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosisThe C-Terminal Domain of the Virulence Factor MgtC Is a Divergent ACT DomainA new dehydratase conferring innate resistance to thiacetazone and intra-amoebal survival of Mycobacterium smegmatisExperimental Models of Foamy Macrophages and Approaches for Dissecting the Mechanisms of Lipid Accumulation and Consumption during Dormancy and Reactivation of TuberculosisLooking through zebrafish to study host-pathogen interactionsLipomannans, but not lipoarabinomannans, purified from Mycobacterium chelonae and Mycobacterium kansasii induce TNF-alpha and IL-8 secretion by a CD14-toll-like receptor 2-dependent mechanismLipomannan and lipoarabinomannan from a clinical isolate of Mycobacterium kansasii: novel structural features and apoptosis-inducing propertiesStructural study of lipomannan and lipoarabinomannan from Mycobacterium chelonae. Presence of unusual components with alpha 1,3-mannopyranose side chainsImmunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogensThe Mycobacterium tuberculosis FAS-II condensing enzymes: their role in mycolic acid biosynthesis, acid-fastness, pathogenesis and in future drug developmentThiacetazone, an antitubercular drug that inhibits cyclopropanation of cell wall mycolic acids in mycobacteriaOleic acid biosynthesis in Plasmodium falciparum: characterization of the stearoyl-CoA desaturase and investigation as a potential therapeutic targetMmPPOX inhibits Mycobacterium tuberculosis lipolytic enzymes belonging to the hormone-sensitive lipase family and alters mycobacterial growthSynthesis, antitubercular activity and mechanism of resistance of highly effective thiacetazone analoguesEthA, a common activator of thiocarbamide-containing drugs acting on different mycobacterial targetsExpression, purification and characterisation of soluble GlfT and the identification of a novel galactofuranosyltransferase Rv3782 involved in priming GlfT-mediated galactan polymerisation in Mycobacterium tuberculosisThe Mycobacterium tuberculosis serine/threonine kinase PknL phosphorylates Rv2175c: mass spectrometric profiling of the activation loop phosphorylation sites and their role in the recruitment of Rv2175cPpm1, a novel polyprenol monophosphomannose synthase from Mycobacterium tuberculosisPhosphorylation of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein reductase MabA regulates mycolic acid biosynthesispH-dependent pore-forming activity of OmpATb from Mycobacterium tuberculosis and characterization of the channel by peptidic dissectionEmbR2, a structural homologue of EmbR, inhibits the Mycobacterium tuberculosis kinase/substrate pair PknH/EmbRDeletion of kasB in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent miceThe condensing activities of the Mycobacterium tuberculosis type II fatty acid synthase are differentially regulated by phosphorylationAn FHA phosphoprotein recognition domain mediates protein EmbR phosphorylation by PknH, a Ser/Thr protein kinase from Mycobacterium tuberculosisMycolic acid biosynthesis and enzymic characterization of the beta-ketoacyl-ACP synthase A-condensing enzyme from Mycobacterium tuberculosisProtein PknE, a novel transmembrane eukaryotic-like serine/threonine kinase from Mycobacterium tuberculosisAn improved method to unravel phosphoacceptors in Ser/Thr protein kinase-phosphorylated substratesPhosphorylation of KasB regulates virulence and acid-fastness in Mycobacterium tuberculosisAcetic Acid, the active component of vinegar, is an effective tuberculocidal disinfectantMycobacterium tuberculosis lipolytic enzymes as potential biomarkers for the diagnosis of active tuberculosisIdentification of KasA as the cellular target of an anti-tubercular scaffoldFrom the characterization of the four serine/threonine protein kinases (PknA/B/G/L) of Corynebacterium glutamicum toward the role of PknA and PknB in cell divisionCrystallization and preliminary X-ray diffraction data of Mycobacterium tuberculosis FbpC1 (Rv3803c).
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Laurent Kremer
@ast
Laurent Kremer
@en
Laurent Kremer
@es
Laurent Kremer
@nl
type
label
Laurent Kremer
@ast
Laurent Kremer
@en
Laurent Kremer
@es
Laurent Kremer
@nl
prefLabel
Laurent Kremer
@ast
Laurent Kremer
@en
Laurent Kremer
@es
Laurent Kremer
@nl
P106
P108
P31
P496
0000-0002-6604-4458