about
High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationshipsCompound Management for Quantitative High-Throughput ScreeningAdvancing Biological Understanding and Therapeutics Discovery with Small-Molecule ProbesComprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-LactamaseDiscovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9aIdentification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBComplementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsQuantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase InhibitorsKinetic, Mutational, and Structural Studies of the Venezuelan Equine Encephalitis Virus Nonstructural Protein 2 Cysteine ProteaseSharing and community curation of mass spectrometry data with Global Natural Products Social Molecular NetworkingOpen Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and BeyondQuantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascadeIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1A high-throughput approach for identification of novel general anestheticsHigh-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin bindingA comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κDiverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionDiscovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapyA high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of AssaysA High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell ModelsAlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein InteractionsHigh-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseA potent and selective inhibitor targeting human and murine 12/15-LOX.High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probeStreamlined system for purifying and quantifying a diverse library of compounds and the effect of compound concentration measurements on the accurate interpretation of biological assay results.Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher diseaseDual-fluorophore quantitative high-throughput screen for inhibitors of BRCT-phosphoprotein interactionA quantitative high-throughput screen identifies potential epigenetic modulators of gene expression.Compound cytotoxicity profiling using quantitative high-throughput screening.Fluorescence spectroscopic profiling of compound libraries.Characterization of chemical libraries for luciferase inhibitory activity.A high throughput fluorescence polarization assay for inhibitors of the GoLoco motif/G-alpha interaction.A robotic platform for quantitative high-throughput screeningOptimization and validation of two miniaturized glucocerebrosidase enzyme assays for high throughput screening.Identification of phosphotyrosine mimetic inhibitors of human tyrosyl-DNA phosphodiesterase I by a novel AlphaScreen high-throughput assayPlatelet 12-LOX is essential for FcγRIIa-mediated platelet activation.
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description
researcher
@en
wetenschapper
@nl
հետազոտող
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name
Ajit Jadhav
@ast
Ajit Jadhav
@en
Ajit Jadhav
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Ajit Jadhav
@nl
type
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Ajit Jadhav
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Ajit Jadhav
@en
Ajit Jadhav
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Ajit Jadhav
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prefLabel
Ajit Jadhav
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Ajit Jadhav
@en
Ajit Jadhav
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Ajit Jadhav
@nl
P106
P1153
14058433100
P21
P31
P496
0000-0001-7955-1451