about
Recent developments in using mechanistic cardiac modelling for drug safety evaluationChaste: an open source C++ library for computational physiology and biology.Hierarchical Bayesian inference for ion channel screening dose-response dataPrediction of Thorough QT study results using action potential simulations based on ion channel screensTen simple rules for effective computational researchEvaluation of an in silico cardiac safety assay: using ion channel screening data to predict QT interval changes in the rabbit ventricular wedge.Variability in high-throughput ion-channel screening data and consequences for cardiac safety assessment.A multiple timescale analysis of a mathematical model of the Wnt/beta-catenin signalling pathway.Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing.Modelling spatially regulated beta-catenin dynamics and invasion in intestinal crypts.mRNA expression levels in failing human hearts predict cellular electrophysiological remodeling: a population-based simulation study.Application of stochastic phenomenological modelling to cell-to-cell and beat-to-beat electrophysiological variability in cardiac tissueCellular cardiac electrophysiology modeling with Chaste and CellML.Simulation of multiple ion channel block provides improved early prediction of compounds' clinical torsadogenic risk.Cardiac tissue slices: preparation, handling, and successful optical mapping.A web portal for in-silico action potential predictionsApplication of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential.Computational assessment of drug-induced effects on the electrocardiogram: from ion channel to body surface potentialsUncertainty and variability in models of the cardiac action potential: Can we build trustworthy models?Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression.Uncertainty and variability in computational and mathematical models of cardiac physiology.Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG.Phenomenological modeling of cell-to-cell and beat-to-beat variability in isolated Guinea Pig ventricular myocytes.Nonclinical cardiovascular safety of pitolisant: comparing International Conference on Harmonization S7B and Comprehensive in vitro Pro-arrhythmia Assay initiative studies.High-throughput functional curation of cellular electrophysiology models.Early afterdepolarisation tendency as a simulated pro-arrhythmic risk indicator.A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt.An integrative computational model for intestinal tissue renewal.Sinusoidal voltage protocols for rapid characterisation of ion channel kinetics.Representation of Multiple Cellular Phenotypes Within Tissue-Level Simulations of Cardiac ElectrophysiologyReproducible model development in the cardiac electrophysiology Web LabReproducible model development in the Cardiac Electrophysiology Web LabSinusoidal Voltage Protocols For Rapid Characterisation Of Ion Channel KineticsVoltage protocol design for determining hERG channel kineticsNovel Voltage Protocols for Determining hERG Channel KineticsIn silico pro-arrhythmia assessment: Can the results of the thorough QT study be predicted?Evaluation of computational modelling as a preclinical proarrhythmic safety assayA local sensitivity analysis method for developing biological models with identifiable parameters: Application to cardiac ionic channel modelling
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P50
description
onderzoeker
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researcher
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հետազոտող
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name
Gary R. Mirams
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Gary R. Mirams
@en
Gary R. Mirams
@es
Gary R. Mirams
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type
label
Gary R. Mirams
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Gary R. Mirams
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Gary R. Mirams
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Gary R. Mirams
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Gary R. Mirams
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Gary R. Mirams
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Gary R. Mirams
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Gary R. Mirams
@nl
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0000-0002-4569-4312