Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
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The biological functions of T helper 17 cell effector cytokines in inflammationInflammatory cytokines in systemic lupus erythematosusFollicular Helper T Cells in Systemic Lupus Erythematosus: Why Should They Be Considered as Interesting Therapeutic Targets?IL-21: roles in immunopathology and cancer therapyThe 4q27 locus and prostate cancer risk.The genetics and epigenetics of autoimmune diseases.Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA).Association between IL-21 gene rs907715 polymorphisms and Graves' disease in a Southern Chinese population.The Production IL-21 and VEGF in UVB-irradiated Human Keratinocyte Cell Line, HaCaTThe IL-2 defect in systemic lupus erythematosus disease has an expansive effect on host immunityInterleukin-21: a new mediator of inflammation in systemic lupus erythematosus.Only one independent genetic association with rheumatoid arthritis within the KIAA1109-TENR-IL2-IL21 locus in Caucasian sample sets: confirmation of association of rs6822844 with rheumatoid arthritis at a genome-wide level of significanceInterleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications.A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap.Gene-gene and gene-sex epistatic interactions of MiR146a, IRF5, IKZF1, ETS1 and IL21 in systemic lupus erythematosusIL-21 and IL-21 receptor expression in lymphocytes and neurons in multiple sclerosis brain.Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosusPolymorphisms of interleukin-21 and interleukin-21-receptor genes confer risk for autoimmune thyroid diseases.Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21Three ulcerative colitis susceptibility loci are associated with primary sclerosing cholangitis and indicate a role for IL2, REL, and CARD9CTLA-4 gene polymorphism and the risk of systemic lupus erythematosus in the Chinese population.The role of cytokines in the pathogenesis and treatment of systemic lupus erythematosusThe dysregulation of cytokine networks in systemic lupus erythematosus.Interleukin-21 gene polymorphisms and chronic hepatitis B infection in a Chinese population.Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study.Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus.Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosusInvestigation of IL-21 gene polymorphisms (rs2221903, rs2055979) in cases with multiple sclerosis of Azerbaijan, Northwest Iran.Increase in IL-21 producing T-cells in patients with systemic lupus erythematosus.Impact of interleukin-21 in the pathogenesis of primary Sjögren's syndrome: increased serum levels of interleukin-21 and its expression in the labial salivary glands.Generation and characterization of human anti-human IL-21 neutralizing monoclonal antibodiesIL-21 promotes lupus-like disease in chronic graft-versus-host disease through both CD4 T cell- and B cell-intrinsic mechanisms.IL-21 acts as a promising therapeutic target in systemic lupus erythematosus by regulating plasma cell differentiation.IL-21 polymorphisms rs907715 and rs2221903 are associated with decreased non-small cell lung cancer susceptibilityIL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.IL-21-stimulated human plasmacytoid dendritic cells secrete granzyme B, which impairs their capacity to induce T-cell proliferation.Interleukin 21: a cytokine/cytokine receptor system that has come of ageIRF-4-binding protein inhibits interleukin-17 and interleukin-21 production by controlling the activity of IRF-4 transcription factor.A critical role for IL-21 receptor signaling in the pathogenesis of systemic lupus erythematosus in BXSB-Yaa mice.IL-21 promotes the production of anti-DNA IgG but is dispensable for kidney damage in lyn-/- mice.
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Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
description
im August 2007 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в серпні 2007
@uk
name
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@en
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@nl
type
label
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@en
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@nl
prefLabel
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@en
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@nl
P2093
P356
P1476
Genetic association of interleukin-21 polymorphisms with systemic lupus erythematosus
@en
P2093
A E Wandstrat
A H Sawalha
E K Wakeland
J Kilpatrick
J T Merrill
K M Kaufman
P304
P356
10.1136/ARD.2007.075424
P407
P577
2007-08-02T00:00:00Z