about
The pre-B cell receptor; selecting for or against autoreactivityThe murine VpreB1 and VpreB2 genes both encode a protein of the surrogate light chain and are co-expressed during B cell developmentBoth the pre-BCR and the IL-7Ralpha are essential for expansion at the pre-BII cell stage in vivoComplementary signaling through flt3 and interleukin-7 receptor alpha is indispensable for fetal and adult B cell genesisSilencing and nuclear repositioning of the lambda5 gene locus at the pre-B cell stage requires Aiolos and OBF-1.Review article: role of the surrogate light chain and the pre-B-cell receptor in mouse B-cell development.The pre-B cell receptor checkpoint.Uncoupling of natural IgE production and CD23 surface expression levelsGene Therapy Induces Antigen-Specific Tolerance in Experimental Collagen-Induced Arthritis.Collagen epitope expression on B cells is sufficient to confer tolerance to collagen-induced arthritisThe Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.Surface mu heavy chain signals down-regulation of the V(D)J-recombinase machinery in the absence of surrogate light chain componentsThe pre-B-cell receptor.The c-myc protein represses the lambda 5 and TdT initiators.CD21 -/low B cells: A Snapshot of a Unique B Cell Subset in Health and Disease.Absence of surrogate light chain results in spontaneous autoreactive germinal centres expanding V(H)81X-expressing B cells.The pre-B-cell receptor induces silencing of VpreB and lambda5 transcription.Two pathways of B-lymphocyte development in mouse bone marrow and the roles of surrogate L chain in this development.Interferon-specific effects on protein synthesis in P3HR-1 cells.The structure of an alternate form of complement C3 that displays costimulatory growth factor activity for B lymphocytes.Pre-B cell-specific lambda 5 gene expression due to suppression in non pre-B cells.Regulation of interleukin 2 gene expression: discrepancy between enhancer activity and endogenous gene expression.B-lineage commitment prior to surface expression of B220 and CD19 on hematopoietic progenitor cells.Age-associated B cells expanded in autoimmune mice are memory cells sharing H-CDR3-selected repertoires.CD21(-/low) B cells in human blood are memory cells.The VpreB1 enhancer drives developmental stage-specific gene expression in vivo.Androgens Regulate Bone Marrow B Lymphopoiesis in Male Mice by Targeting Osteoblast-Lineage CellsRegulation of immunoglobulin gene expression in trans by phorbol estersTranscriptional regulation of immunoglobulin expression in a chronic lymphocytic leukemia cell lineEffects of phorbol esters on B-cell gene expressionVpreB1/VpreB2/lambda 5 triple-deficient mice show impaired B cell development but functional allelic exclusion of the IgH locusThe PI3K p110delta is required for down-regulation of RAG expression in immature B cellsImpaired B-1 and B-2 B cell development and atypical splenic B cell structures in IL-7 receptor-deficient miceCensoring of autoreactive B cell development by the pre-B cell receptorOnly VpreB1, but not VpreB2, is expressed at levels which allow normal development of B cellsOX40 ligand and CD30 ligand are expressed on adult but not neonatal CD4+CD3- inducer cells: evidence that IL-7 signals regulate CD30 ligand but not OX40 ligand expressionSurrogate light chain is required for central and peripheral B-cell tolerance and inhibits anti-DNA antibody production by marginal zone B cells
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description
researcher ORCID ID = 0000-0003-3415-0560
@en
wetenschapper
@nl
name
Inga-Lill Martensson
@ast
Inga-Lill Martensson
@en
Inga-Lill Martensson
@es
Inga-Lill Martensson
@nl
type
label
Inga-Lill Martensson
@ast
Inga-Lill Martensson
@en
Inga-Lill Martensson
@es
Inga-Lill Martensson
@nl
prefLabel
Inga-Lill Martensson
@ast
Inga-Lill Martensson
@en
Inga-Lill Martensson
@es
Inga-Lill Martensson
@nl
P106
P21
P31
P496
0000-0003-3415-0560