SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis
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Atypical teratoid/rhabdoid tumors: challenges and search for solutionsA Comprehensive Review of Pediatric Tumors and Associated Cancer Predisposition Syndromes.DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.The hereditary nature of small cell carcinoma of the ovary, hypercalcemic type: two new familial cases.Germline SMARCA4 mutations in patients with ovarian small cell carcinoma of hypercalcemic type.Recent developments in brain tumor predisposing syndromes.Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).Molecular analyses reveal close similarities between small cell carcinoma of the ovary, hypercalcemic type and atypical teratoid/rhabdoid tumor.Atypical teratoid/rhabdoid tumors-current concepts, advances in biology, and potential future therapies.Improved 6-year overall survival in AT/RT - results of the registry study Rhabdoid 2007.Molecular biology of pediatric brain tumors and impact on novel therapies.SMARCA4/Brg1 coordinates genetic and epigenetic networks underlying Shh-type medulloblastoma development.Small cell undifferentiated (SCUD) hepatoblastomas: All malignant rhabdoid tumors?Clinical, morphological and immunohistochemical evidence that small-cell carcinoma of the ovary of hypercalcaemic type (SCCOHT) may be a primitive germ-cell neoplasm.Modeling and Targeting MYC Genes in Childhood Brain Tumors.Clinicopathological and molecular characterization of SMARCA4-deficient thoracic sarcomas with comparison to potentially related entities.Combined BRD4 and CDK9 inhibition as a new therapeutic approach in malignant rhabdoid tumors.SMARCA4 germline gene mutation in a patient with epithelial ovarian: A case report.Atypical teratoid/rhabdoid tumor with retained INI1 (SMARCB1) expression and loss of BRG1 (SMARCA4).SMARCA4 inactivation defines a group of undifferentiated thoracic malignancies transcriptionally related to BAF-deficient sarcomas.Adult-onset atypical teratoid/rhabdoid tumor featuring long spindle cells with nuclear palisading and perivascular pseudorosettes.Malignant rhabdoid tumors originating within and outside the central nervous system are clinically and molecularly heterogeneous.Description of a new oncogenic mechanism for atypical teratoid rhabdoid tumors in patients with ring chromosome 22.
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P2860
SMARCA4-mutated atypical teratoid/rhabdoid tumors are associated with inherited germline alterations and poor prognosis
description
article
@en
im September 2014 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
name
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@en
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@nl
type
label
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@en
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@nl
prefLabel
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@en
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@nl
P2093
P50
P1476
SMARCA4-mutated atypical terat ...... alterations and poor prognosis
@en
P2093
Ali H Alassiri
Ali H. Alassiri
Elisabetta Viscardi
Helen Toledano
Inga Nagel
Irene Schmid
Kerstin Bartelheim
Leora Witkowski
Marc Rosenblum
Matthew J. Betts
P2888
P356
10.1007/S00401-014-1323-X
P407
P50
P577
2014-07-25T00:00:00Z
2014-09-01T00:00:00Z