A new role for the Krüppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function
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The pathobiology of splicingUp-regulation of tumor suppressor genes by exogenous dhC16-Cer contributes to its anti-cancer activity in primary effusion lymphoma.Krüppel-like factor 6 expression changes during trophoblast syncytialization and transactivates ßhCG and PSG placental genes.Nuclear expression of KLF6 tumor suppressor factor is highly associated with overexpression of ERBB2 oncoprotein in ductal breast carcinomasKLF6-SV1 is a novel antiapoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.Aberrant expression of krUppel-like factor 6 protein in colorectal cancers.Long-term survival of hydrated resting eggs from Brachionus plicatilis.Functional role of the KLF6 tumour suppressor gene in gastric cancer.Molecular mechanisms of the suppression of axon regeneration by KLF transcription factors.Disruption of an SP2/KLF6 repression complex by SHP is required for farnesoid X receptor-induced endothelial cell migration.PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins.KLF6-SV1 overexpression accelerates human and mouse prostate cancer progression and metastasis.Down-regulation of the oncogene PTTG1 via the KLF6 tumor suppressor during induction of myeloid differentiation.Myeloid dendritic cells induce HIV-1 latency in non-proliferating CD4+ T cells.Inactivation of the tumor suppressor Krüppel-like factor 6 (KLF6) by mutation or decreased expression in hepatocellular carcinomas.Krüppel-like factor KLF9 regulates PPARγ transactivation at the middle stage of adipogenesis.Carcinogen-induced hepatic tumors in KLF6+/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.Increased H3K9me3 drives dedifferentiated phenotype via KLF6 repression in liposarcoma.Enhanced hepatocarcinogenesis in mouse models and human hepatocellular carcinoma by coordinate KLF6 depletion and increased messenger RNA splicing.A Novel Mechanism of PPARgamma Regulation of TGFbeta1: Implication in Cancer BiologyRas promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor in hepatocellular carcinoma.Regions outside the DNA-binding domain are critical for proper in vivo specificity of an archetypal zinc finger transcription factorGSK3β phosphorylation of the KLF6 tumor suppressor promotes its transactivation of p21.A novel regulator of human villous trophoblast fusion: the Krüppel-like factor 6.A small interfering RNA targeting the KLF6 splice variant, KLF6-SV1, as gene therapy for gastric cancer.A functional role for KLF6-SV1 in lung adenocarcinoma prognosis and chemotherapy response.KLF6 transcription factor protects hepatocellular carcinoma-derived cells from apoptosis.KLF6 degradation after apoptotic DNA damage.E-cadherin is a novel transcriptional target of the KLF6 tumor suppressor.Genetic alterations of the KLF6 gene in colorectal cancers.KLF6 and TP53 mutations are a rare event in prostate cancer: distinguishing between Taq polymerase artifacts and true mutations.Krüppel-like factors: Crippling and un-crippling metabolic pathways.Silencing of the transcription factor KLF6 by siRNA leads to cell cycle arrest and sensitizes cells to apoptosis induced by DNA damage
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A new role for the Krüppel-like transcription factor KLF6 as an inhibitor of c-Jun proto-oncoprotein function
description
im September 2004 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована у вересні 2004
@uk
name
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@en
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@nl
type
label
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@en
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@nl
prefLabel
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@en
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@nl
P2093
P2860
P356
P1433
P1476
A new role for the Krüppel-lik ...... Jun proto-oncoprotein function
@en
P2093
Bruno Chatton
Claudio C Prieto
Daniela A Slavin
Fernando J López-Díaz
Nicolás P Koritschoner
P2860
P2888
P304
P356
10.1038/SJ.ONC.1208020
P407
P577
2004-09-20T00:00:00Z