Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
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STIM1 couples to ORAI1 via an intramolecular transition into an extended conformationA novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cellsSTIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and toleranceThe STIM1/Orai signaling machineryMolecular regulation of CRAC channels and their role in lymphocyte functionThe TR (i)P to Ca²⁺ signaling just got STIMy: an update on STIM1 activated TRPC channelsClinical, histological and genetic characterisation of patients with tubular aggregate myopathy caused by mutations in STIM1Mapping the interacting domains of STIM1 and Orai1 in Ca2+ release-activated Ca2+ channel activationSTIM1 gates the store-operated calcium channel ORAI1 in vitroConformational Changes in the Orai1 C-Terminus Evoked by STIM1 BindingNative STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neuronsSome assembly required: constructing the elementary units of store-operated Ca2+ entry.Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.Hair loss and defective T- and B-cell function in mice lacking ORAI1STIMulating store-operated Ca(2+) entry.Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletionSingle-molecule analysis of diffusion and trapping of STIM1 and Orai1 at endoplasmic reticulum-plasma membrane junctions.Store-operated calcium entry promotes the degradation of the transcription factor Sp4 in resting neurons.The Drosophila STIM1 orthologue, dSTIM, has roles in cell fate specification and tissue patterning.Tetrameric Orai1 is a teardrop-shaped molecule with a long, tapered cytoplasmic domainRole of phosphoinositides in STIM1 dynamics and store-operated calcium entry.Molecular basis of calcium signaling in lymphocytes: STIM and ORAIEssential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Sequential Steps of CRAC Channel Activation.STIM proteins and the endoplasmic reticulum-plasma membrane junctions.Differential STIM1 expression in T and B cell subsets suggests a role in determining antigen receptor signal amplitudeVisualisation and identification of the interaction between STIM1s in resting cells.Pharmacology of store-operated calcium channelsRational design of true monomeric and bright photoactivatable fluorescent proteins.Orai1 interacts with STIM1 and mediates capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells.Competitive modulation of Ca2+ release-activated Ca2+ channel gating by STIM1 and 2-aminoethyldiphenyl borateCalcium signaling in lymphocytesFormation of STIM and Orai complexes: puncta and distal caps.Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells.STIM and Orai: the long-awaited constituents of store-operated calcium entryStoichiometric requirements for trapping and gating of Ca2+ release-activated Ca2+ (CRAC) channels by stromal interaction molecule 1 (STIM1).Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesisSTIM2 enhances receptor-stimulated Ca²⁺ signaling by promoting recruitment of STIM1 to the endoplasmic reticulum-plasma membrane junctions.
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P2860
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
description
im Dezember 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific article published 2006 in Biochemical and Biophysical Research Communications
@en
wetenschappelijk artikel
@nl
наукова стаття, опублікована в грудні 2006
@uk
name
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
@en
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
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type
label
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
@en
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
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prefLabel
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
@en
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
@nl
P2093
P1476
Aggregation of STIM1 underneath the plasma membrane induces clustering of Orai1
@en
P2093
Pingyong Xu
Xiaoqing Yu
Zhengzheng Li
P304
P356
10.1016/J.BBRC.2006.09.134
P407
P50
P577
2006-10-04T00:00:00Z