about
Determining biophysical protein stability in lysates by a fast proteolysis assay, FASTppMessing up disorder: how do missense mutations in the tumor suppressor protein APC lead to cancer?Large extent of disorder in Adenomatous Polyposis Coli offers a strategy to guard Wnt signalling against point mutationsTumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsFOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSPLoss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of DvlLoss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complexDeubiquitination of Dishevelled by Usp14 is required for Wnt signalingWnt signaling through inhibition of β-catenin degradation in an intact Axin1 complexAxin cancer mutants form nanoaggregates to rewire the Wnt signaling networkCritical scaffolding regions of the tumor suppressor Axin1 are natively unfoldedStabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.Stochastic machines as a colocalization mechanism for scaffold protein functionClass I negative CD8 T cells reveal the confounding role of peptide-transfer onto CD8 T cells stimulated with soluble H2-Kb molecules.Wnt signalling induces accumulation of phosphorylated β-catenin in two distinct cytosolic complexes.Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in FrizzledLoss-of-Function Mutations in the WNT Co-receptor LRP6 Cause Autosomal-Dominant Oligodontia.The various roles of ubiquitin in Wnt pathway regulation.DEP domains: structurally similar but functionally different.USP7 is essential for maintaining Rad18 stability and DNA damage tolerance.Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.Molecular regulation and pharmacological targeting of the β-catenin destruction complex.Hyperubiquitylation of wild-type p53 contributes to cytoplasmic sequestration in neuroblastoma.Mst4 and Ezrin induce brush borders downstream of the Lkb1/Strad/Mo25 polarization complex.How antibodies to a ubiquitous cytoplasmic enzyme may provoke joint-specific autoimmune disease.The ubiquitin-proteasome pathway in thymocyte apoptosis: caspase-dependent processing of the deubiquitinating enzyme USP7 (HAUSP).Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7.Canonical Wnt signaling negatively modulates regulatory T cell function.Redox Balance Alterations and Hyporesponsiveness of Synovial T Cells in Rheumatoid Arthritis.In vivo role of lipid adducts on Wingless.Syndecan-1 promotes Wnt/β-catenin signaling in multiple myeloma by presenting Wnts and R-spondins.Variants in members of the cadherin-catenin complex, CDH1 and CTNND1, cause blepharocheilodontic syndrome.Loss of CYLD expression unleashes Wnt signaling in multiple myeloma and is associated with aggressive disease.Specific Labeling of Stem Cell Activity in Human Colorectal Organoids Using an ASCL2-Responsive Minigene.Heterogeneity of the circulating human CD4+ T cell population. Further evidence that the CD4+CD45RA-CD27- T cell subset contains specialized primed T cells.Visualization of a short-range Wnt gradient in the intestinal stem-cell niche.TMEM59 potentiates Wnt signaling by promoting signalosome formation.Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMRTales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer
P50
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P50
description
researcher, ORCID id # 0000-0001-6885-5361
@en
wetenschapper
@nl
name
Madelon M Maurice
@ast
Madelon M Maurice
@en
Madelon M Maurice
@es
Madelon M Maurice
@nl
type
label
Madelon M Maurice
@ast
Madelon M Maurice
@en
Madelon M Maurice
@es
Madelon M Maurice
@nl
altLabel
Madelon Maurice
@en
prefLabel
Madelon M Maurice
@ast
Madelon M Maurice
@en
Madelon M Maurice
@es
Madelon M Maurice
@nl
P106
P1153
57201600466
P21
P31
P496
0000-0001-6885-5361