about
B Cell Receptor Activation Predominantly Regulates AKT-mTORC1/2 Substrates Functionally Related to RNA ProcessingANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain libraryRegulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54).Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia modelTEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.Substitution scanning identifies a novel, catalytically active ibrutinib-resistant BTK cysteine 481 to threonine (C481T) variant.Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells.Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70.Anti-leukaemic effects induced by APR-246 are dependent on induction of oxidative stress and the NFE2L2/HMOX1 axis that can be targeted by PI3K and mTOR inhibitors in acute myeloid leukaemia cells.Terminating B cell receptor signaling.Protein kinase B (AKT) regulates SYK activity and shuttling through 14-3-3 and importin 7.Translocation-generated ITK-FER and ITK-SYK fusions induce STAT3 phosphorylation and CD69 expressionMapping 123 million neonatal, infant and child deaths between 2000 and 2017The kidney injury caused by the onset of acute graft-versus-host disease is associated with down-regulation of αKlotho
P50
Q28553375-7EEBFF5D-BA11-42FF-A886-DAEEBDBA60C5Q30008753-6DC99A9F-93F5-460F-9CC8-BED6766AF2E9Q30010124-E521A686-43BA-410B-8879-573F85DEB9DFQ34117470-94E4C46F-6B23-4EA4-896B-A0F7D76A0532Q37868757-27B5BF12-0673-481F-B411-229E00E15AE5Q38765458-26B00413-1CD4-4B1F-A65A-CAA4EBB2C066Q39141247-2BEB7A88-A687-4BA6-8B18-BCCEB187002FQ41463018-71173449-B4C5-46BB-8122-9368241DE5E3Q46577501-B971E339-2292-4497-88D0-43250E81E8FDQ47105054-2FE40669-A65F-4F92-834D-DAA6382AD80CQ51661262-5015BFBB-E29F-41C6-B8E2-DEF871116FC4Q57279324-46D7E5DB-0EDA-40ED-B276-6E604937D759Q90754787-600F3492-7176-494F-B9AC-4B84E1A8C840Q91774335-7DE565EF-BD0A-4EBB-A10D-83248E712F9C
P50
description
researcher ORCID ID = 0000-0001-9201-0991
@en
wetenschapper
@nl
name
Dara K Mohammad
@ast
Dara K Mohammad
@en
Dara K Mohammad
@nl
type
label
Dara K Mohammad
@ast
Dara K Mohammad
@en
Dara K Mohammad
@nl
prefLabel
Dara K Mohammad
@ast
Dara K Mohammad
@en
Dara K Mohammad
@nl
P106
P31
P496
0000-0001-9201-0991