about
Engineering higher affinity T cell receptors using a T cell display system.Identification and engineering of human variable regions that allow expression of stable single-chain T cell receptors.A novel T cell receptor single-chain signaling complex mediates antigen-specific T cell activity and tumor controlOpposite effects of endogenous peptide-MHC class I on T cell activity in the presence and absence of CD8.Single-chain VαVβ T-cell receptors function without mispairing with endogenous TCR chains.A sensitivity scale for targeting T cells with chimeric antigen receptors (CARs) and bispecific T-cell Engagers (BiTEs).Structural features of T cell receptor variable regions that enhance domain stability and enable expression as single-chain ValphaVbeta fragmentsTargeting PD-1 or PD-L1 in Metastatic Kidney Cancer: Combination Therapy in the First-Line Setting
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description
researcher ORCID ID = 0000-0003-3963-5751
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wetenschapper
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name
David H Aggen
@ast
David H Aggen
@en
David H Aggen
@es
David H Aggen
@nl
type
label
David H Aggen
@ast
David H Aggen
@en
David H Aggen
@es
David H Aggen
@nl
prefLabel
David H Aggen
@ast
David H Aggen
@en
David H Aggen
@es
David H Aggen
@nl
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6504049665
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P31
P496
0000-0003-3963-5751