Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

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Challenges in searching for therapeutics against Botulinum Neurotoxins.

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Q39167871-EC39B800-EF61-4568-B9AD-863BCA01348C

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Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

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im Januar 2012 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 25 January 2012

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wetenschappelijk artikel

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наукова стаття, опублікована у 2012

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Discovery of a fluorene class ...... erotype E by virtual screening

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Discovery of a fluorene class ...... erotype E by virtual screening

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Discovery of a fluorene class ...... erotype E by virtual screening

@en

Discovery of a fluorene class ...... erotype E by virtual screening

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Discovery of a fluorene class ...... erotype E by virtual screening

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Discovery of a fluorene class ...... erotype E by virtual screening

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P1476

Discovery of a fluorene class ...... erotype E by virtual screening

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P2093

Rakhi Agarwal

http://www.w3.org/2001/XMLSchema#string

Subramanyam Swaminathan

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SNAP-25 Substrate Peptide (Residues 180-183) Binds to but Bypasses Cleavage by Catalytically Active Clostridium botulinum Neurotoxin E

Structural Characterization of Three Novel Hydroxamate-Based Zinc Chelating Inhibitors of the Clostridium botulinum Serotype A Neurotoxin Light Chain Metalloprotease Reveals a Compact Binding Site Resulting from 60/70 Loop Flexibility

Small molecules showing significant protection of mice against botulinum neurotoxin serotype A

Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.

A cross-over inhibitor of the botulinum neurotoxin light chain B: a natural product implicating an exosite mechanism of action

Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype A

A molecular basis underlying differences in the toxicity of botulinum serotypes A and E.

Structure and function of tetanus and botulinum neurotoxins.

Interaction of 125I-labeled botulinum neurotoxins with nerve terminals. II. Autoradiographic evidence for its uptake into motor nerves by acceptor-mediated endocytosis.

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2412-2414

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scholarly article

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10.1039/C2CC17158A

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English

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P478

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Gyanendra Kumar

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2012-01-25T00:00:00Z

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22274537

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Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

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P2860

P2860

Discovery of a fluorene class of compounds as inhibitors of botulinum neurotoxin serotype E by virtual screening

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P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698