Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue
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Insight into a natural Diels-Alder reaction from the structure of macrophomate synthaseImpact of scaffold rigidity on the design and evolution of an artificial Diels-AlderaseStrategies for discovery and improvement of enzyme function: state of the art and opportunitiesDiels-Alderases.Optimising stereoselectivity in intramolecular Diels-Alder reactions of pentadienyl acrylates: synthetic and computational investigations into the "steric directing group" approach.Recent advances in the field of bioactive tetronates.Active site mutagenesis of the putative Diels-Alderase macrophomate synthase.Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds.Global gene expression patterns of grass carp following compensatory growth.Natural insights for chemical biologists.The biosynthesis, molecular genetics and enzymology of the polyketide-derived metabolites.Involvement of Lipocalin-like CghA in Decalin-Forming Stereoselective Intramolecular [4+2] Cycloaddition.Structural analysis of protein-protein interactions in type I polyketide synthasesThe Diels--Alder reaction in total synthesis.Artificial metalloenzymes as catalysts in stereoselective Diels-Alder reactions.Molecular diversity sculpted by fungal PKS-NRPS hybrids.Natural products containing 'decalin' motif in microorganisms.Explorations of fungal biosynthesis of reduced polyketides - a personal viewpoint.Cyclization of polyketides and non-ribosomal peptides on and off their assembly lines.Tanzawaic acids isolated from a marine-derived fungus of the genus Penicillium with cytotoxic activities.Elucidation of biosynthetic pathways of natural products.Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids.Biochemistry. Reengineering enzymes.Production of lovastatin examined by an integrated approach based on chemometrics and DOSY-NMR.Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: evidence for enzyme catalysis and increased antibacterial activity.Functional Analysis of the Fusarielin Biosynthetic Gene Cluster.Stereopermutation on the Putative Structure of the Marine Natural Product Mucosin.An enzymatic [4+2] cyclization cascade creates the pentacyclic core of pyrroindomycins.Special issue of The Journal of Antibiotics dedicated to the late Professor C Richard Hutchinson.Biochemistry: life imitates art.Synthetic studies on the bioactive tetramic acid JBIR-22 using a late stage Diels-Alder reaction.
P2860
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P2860
Lovastatin Nonaketide Synthase Catalyzes an Intramolecular Diels−Alder Reaction of a Substrate Analogue
description
article
@en
im November 2000 veröffentlichter wissenschaftlicher Artikel
@de
wetenschappelijk artikel
@nl
наукова стаття, опублікована в листопаді 2000
@uk
name
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@en
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@nl
type
label
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@en
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@nl
prefLabel
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@en
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@nl
P2093
P356
P1476
Lovastatin Nonaketide Synthase ...... action of a Substrate Analogue
@en
P2093
C. Richard Hutchinson
David J. Witter
Johan P. Van den Heever
John C. Vederas
Jonathan Kennedy
Karine Auclair
P304
11519-11520
P356
10.1021/JA003216+
P407
P577
2000-11-01T00:00:00Z