Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells

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Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells

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http://www.wikidata.org/entity/Q59132138

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im Januar 2018 veröffentlichter wissenschaftlicher Artikel

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scientific article published on 02 November 2018

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wetenschappelijk artikel

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наукова стаття, опублікована у 2018

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name

Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

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Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

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Item

label

Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

@en

Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

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Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

@en

Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

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P1476

Combined Metabolic Targeting W ...... n Acute Myeloid Leukemia Cells

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Anton Seilbeck

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Astrid Schmidt

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Christina Brummer

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Christina Bruss

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Eva Gottfried

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Ines Ugele

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Kathrin Hammon

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Kathrin Renner

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Katrin Peter

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Katrin Singer

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P2860

A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors

New aspects of an old drug--diclofenac targets MYC and glucose metabolism in tumor cells

Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity

THE METABOLISM OF TUMORS IN THE BODY

c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

The multikinase inhibitor Sorafenib enhances glycolysis and synergizes with glycolysis blockade for cancer cell killing.

Repurposing Drugs in Oncology (ReDO)-diclofenac as an anti-cancer agent

AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/β-catenin signaling pathway

TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

Repurposing metformin for the prevention of cancer and cancer recurrence.

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1258

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scholarly article

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10.3389/FPHAR.2018.01258

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English

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Sebastian Klobuch

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2018-11-02T00:00:00Z

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30450049

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P921

metformin

diclofenac

leukemia

P932

6224440

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