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Characterization of homologous recombination induced by replication inhibition in mammalian cellsAnalysis of intrachromosomal homologous recombination in mammalian cell, using tandem repeat sequences.Is homologous recombination really an error-free process?The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.The chromatin assembly factor 1 promotes Rad51-dependent template switches at replication forks by counteracting D-loop disassembly by the RecQ-type helicase Rqh1Stress activated protein kinase pathway modulates homologous recombination in fission yeastThe causes of replication stress and their consequences on genome stability and cell fate.Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-linksPyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.Checkpoint responses to replication fork barriers.Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpointArrested replication fork processing: interplay between checkpoints and recombination.Replication stress and genome rearrangements: lessons from yeast models.Impediments to replication fork movement: stabilisation, reactivation and genome instability.Replication stress-induced genome instability: the dark side of replication maintenance by homologous recombination.DNA damage: RNA-binding proteins protect from near and far.Homologous recombination as a replication fork escort: fork-protection and recovery.A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation.Characterization of mammalian RAD51 double strand break repair using non-lethal dominant-negative forms.Unique genome replication mechanism of the archaeal virus AFV1.Nearby inverted repeats fuse to generate acentric and dicentric palindromic chromosomes by a replication template exchange mechanism.Role of RAD51 in sister-chromatid exchanges in mammalian cells.Unprotected Replication Forks Are Converted into Mitotic Sister Chromatid Bridges.Chronic exposure to sublethal doses of radiation mimetic Zeocin selects for clones deficient in homologous recombination.Overexpression of mammalian Rad51 does not stimulate tumorigenesis while a dominant-negative Rad51 affects centrosome fragmentation, ploidy and stimulates tumorigenesis, in p53-defective CHO cells.Preserving replication fork integrity and competence via the homologous recombination pathwayHomologous Recombination Restarts Blocked Replication Forks at the Expense of Genome Rearrangements by Template ExchangeGuidelines for DNA recombination and repair studies: Cellular assays of DNA repair pathwaysAnalyzing the Response to Dysfunction Replication Forks Using the RTS1 Barrier System in Fission YeastGross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork BarrierInactivation of the RAD51 recombination pathway stimulates UV-induced mutagenesis in mammalian cellsChromatin remodeler Fft3 plays a dual role at blocked DNA replication forksHistone deposition promotes recombination-dependent replication at arrested forksUnstable genomes promote inflammationMre11 exonuclease activity removes the chain-terminating nucleoside analog gemcitabine from the nascent strand during DNA replication
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description
researcher ORCID ID = 0000-0002-1403-3204
@en
wetenschapper
@nl
name
Sarah Lambert
@ast
Sarah Lambert
@en
Sarah Lambert
@es
Sarah Lambert
@nl
type
label
Sarah Lambert
@ast
Sarah Lambert
@en
Sarah Lambert
@es
Sarah Lambert
@nl
prefLabel
Sarah Lambert
@ast
Sarah Lambert
@en
Sarah Lambert
@es
Sarah Lambert
@nl
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P31
P496
0000-0002-1403-3204