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Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cellsA dual-Ca2+-sensor model for neurotransmitter release in a central synapseCalmodulin binding to the C-terminus of the small-conductance Ca2+-activated K+ channel hSK1 is affected by alternative splicingSynaptotagmin-2 is essential for survival and contributes to Ca2+ triggering of neurotransmitter release in central and neuromuscular synapsesMunc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cellsMuc5b is required for airway defenceEssential role for mast cell tryptase in acute experimental colitisCholinergic efferent synaptic transmission regulates the maturation of auditory hair cell ribbon synapses.Signal transducer and activator of transcription 3 (STAT3) regulates collagen-induced platelet aggregation independently of its transcription factor activity.A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis.The inflammatory response after an epidermal burn depends on the activities of mouse mast cell proteases 4 and 5.Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis.Compound vesicle fusion increases quantal size and potentiates synaptic transmissionMast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formationMast cell restricted mouse and human tryptase·heparin complexes hinder thrombin-induced coagulation of plasma and the generation of fibrin by proteolytically destroying fibrinogenCentral role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elementsStimulation of lung innate immunity protects against lethal pneumococcal pneumonia in miceProtease-proteoglycan complexes of mouse and human mast cells and importance of their beta-tryptase-heparin complexes in inflammation and innate immunity.Mast cell-restricted tryptases: structure and function in inflammation and pathogen defense.Ca(2+) and calmodulin initiate all forms of endocytosis during depolarization at a nerve terminal.Mast cells contribute to autoimmune inflammatory arthritis via their tryptase/heparin complexes.Mast cell-restricted, tetramer-forming tryptases induce aggrecanolysis in articular cartilage by activating matrix metalloproteinase-3 and -13 zymogensSynaptotagmin-2 controls regulated exocytosis but not other secretory responses of mast cells.Expression and transcriptional regulation of Munc18 isoforms in mast cells.The Diacylglycerol-dependent translocation of ras guanine nucleotide-releasing protein 4 inside a human mast cell line results in substantial phenotypic changes, including expression of interleukin 13 receptor alpha2.Lung epithelial cells are essential effectors of inducible resistance to pneumonia.Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum.The mouse mast cell-restricted tetramer-forming tryptases mouse mast cell protease 6 and mouse mast cell protease 7 are critical mediators in inflammatory arthritis.The mast cell-restricted tryptase mMCP-6 has a critical immunoprotective role in bacterial infections.Inhaled corticosteroids stabilize constrictive bronchiolitis after hematopoietic stem cell transplantation.Munc13 proteins control regulated exocytosis in mast cells.Atrial natriuretic peptide modulates alveolar type 2 cell adenylyl and guanylyl cyclases and inhibits surfactant secretion.Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle regulated exocytosis in mast cells.Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation.A 62-year-old man with shoulder painBronchoscopic Laser Interstitial Thermal Therapy: An Experimental Study in Normal Porcine Lung ParenchymaMunc18-2, but not Munc18-1 or Munc18-3, regulates platelet exocytosis, hemostasis, and thrombosis
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description
researcher ORCID ID = 0000-0002-0146-0768
@en
wetenschapper
@nl
name
Roberto Adachi
@ast
Roberto Adachi
@en
Roberto Adachi
@es
Roberto Adachi
@nl
type
label
Roberto Adachi
@ast
Roberto Adachi
@en
Roberto Adachi
@es
Roberto Adachi
@nl
prefLabel
Roberto Adachi
@ast
Roberto Adachi
@en
Roberto Adachi
@es
Roberto Adachi
@nl
P1153
16303328000
P21
P31
P496
0000-0002-0146-0768