about
The dendritic cell receptor Clec9A binds damaged cells via exposed actin filamentsDual requirement for the ETS transcription factors Fli-1 and Erg in hematopoietic stem cells and the megakaryocyte lineage.Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion.Deciphering the molecular and biologic processes that mediate histone deacetylase inhibitor-induced thrombocytopenia.Bcl-xL-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets.Megakaryocytes possess a functional intrinsic apoptosis pathway that must be restrained to survive and produce platelets.Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function.A model for studying the hemostatic consumption or destruction of plateletsExpansion of the neonatal platelet mass is achieved via an extension of platelet lifespan.Platelet production proceeds independently of the intrinsic and extrinsic apoptosis pathways.Effect of thrombopoietin receptor agonists on the apoptotic profile of platelets in patients with chronic immune thrombocytopenia.Mouse prenatal platelet-forming lineages share a core transcriptional program but divergent dependence on MPL.Regulation of platelet lifespan by apoptosis.The Pseudokinase MLKL and the Kinase RIPK3 Have Distinct Roles in Autoimmune Disease Caused by Loss of Death-Receptor-Induced Apoptosis.Dual roles for hepatic lectin receptors in the clearance of chilled plateletsProapoptotic Bak and Bax guard against fatal systemic and organ-specific autoimmune diseaseMpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation.A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo.Regulation of platelet membrane protein shedding in health and disease.Polycomb repressive complex 2 component Suz12 is required for hematopoietic stem cell function and lymphopoiesis.Platelet senescence is regulated by an internal timer, not damage inflicted by hits.Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function.Neutrophil macroaggregates promote widespread pulmonary thrombosis after gut ischemia.Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion-methyl-d-aspartate receptor mediated calcium influx supports in vitro differentiation of normal mouse megakaryocytes but proliferation of leukemic cell linesPlatelets disrupt vasculogenic mimicry by cancer cellsTargeting platelets for improved outcome in KRAS-driven lung adenocarcinomaA missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction
P50
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P50
description
researcher ORCID ID = 0000-0001-6478-5204
@en
wetenschapper
@nl
name
Emma C Josefsson
@ast
Emma C Josefsson
@en
Emma C Josefsson
@es
Emma C Josefsson
@nl
type
label
Emma C Josefsson
@ast
Emma C Josefsson
@en
Emma C Josefsson
@es
Emma C Josefsson
@nl
prefLabel
Emma C Josefsson
@ast
Emma C Josefsson
@en
Emma C Josefsson
@es
Emma C Josefsson
@nl
P106
P21
P31
P496
0000-0001-6478-5204