about
The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathwayHistone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio.Fenretinide-induced caspase-8 activation and apoptosis in an established model of metastatic neuroblastoma.The molecular basis of MHC class II deficiency and transcriptional control of MHC class II gene expression.Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cellsLessons from the bare lymphocyte syndrome: molecular mechanisms regulating MHC class II expression.Involvement of the CXCR7/CXCR4/CXCL12 axis in the malignant progression of human neuroblastoma.CIITA is a transcriptional coactivator that is recruited to MHC class II promoters by multiple synergistic interactions with an enhanceosome complexThe CXCR4/CXCR7/CXCL12 Axis Is Involved in a Secondary but Complex Control of Neuroblastoma Metastatic Cell Homing.Aldehyde dehydrogenase activity plays a Key role in the aggressive phenotype of neuroblastoma.Maturation of dendritic cells is accompanied by rapid transcriptional silencing of class II transactivator (CIITA) expression.Individual caspase-10 isoforms play distinct and opposing roles in the initiation of death receptor-mediated tumour cell apoptosis.Escape of human cytomegalovirus from HLA-DR-restricted CD4(+) T-cell response is mediated by repression of gamma interferon-induced class II transactivator expressionPersistent inhibition of FLIP(L) expression by lentiviral small hairpin RNA delivery restores death-receptor-induced apoptosis in neuroblastoma cells.Molecular cytogenetic characterization of doxorubicin-resistant neuroblastoma cell lines: evidence that acquired multidrug resistance results from a unique large amplification of the 7q21 region.The S box of major histocompatibility complex class II promoters is a key determinant for recruitment of the transcriptional co-activator CIITA.Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-xL and RIP.Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8.Dendritic cells and differential usage of the MHC class II transactivator promoters in the central nervous system in experimental autoimmune encephalitisActivation of the MHC class II transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1CIITA-induced occupation of MHC class II promoters is independent of the cooperative stabilization of the promoter-bound multi-protein complexes
P50
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P50
description
researcher ORCID ID = 0000-0001-8274-0907
@en
wetenschapper
@nl
name
Annick Mühlethaler-Mottet
@ast
Annick Mühlethaler-Mottet
@en
Annick Mühlethaler-Mottet
@nl
type
label
Annick Mühlethaler-Mottet
@ast
Annick Mühlethaler-Mottet
@en
Annick Mühlethaler-Mottet
@nl
prefLabel
Annick Mühlethaler-Mottet
@ast
Annick Mühlethaler-Mottet
@en
Annick Mühlethaler-Mottet
@nl
P106
P31
P496
0000-0001-8274-0907