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Influence of trifluoroethanol on membrane interfacial anchoring interactions of transmembrane alpha-helical peptides.Synthesis and structural investigations of N-alkylated beta-peptidosulfonamide-peptide hybrids of the amyloidogenic amylin(20-29) sequence: Implications of supramolecular folding for the design of peptide-based bionanomaterials.Is there a preferential interaction between cholesterol and tryptophan residues in membrane proteins?Membrane-spanning peptides induce phospholipid flop: a model for phospholipid translocation across the inner membrane of E. coli.Tilt angles of transmembrane model peptides in oriented and non-oriented lipid bilayers as determined by 2H solid-state NMR.Backbone-modified amylin derivatives: implications for amyloid inhibitor design and as template for self-assembling bionanomaterials.Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry.Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy.Synthesis and applications of biomedical and pharmaceutical polymers via click chemistry methodologies.Synthesis of bicyclic alkene-/alkane-bridged nisin mimics by ring-closing metathesis and their biochemical evaluation as lipid II binders: toward the design of potential novel antibiotics.A micelle-shedding thermosensitive hydrogel as sustained release formulation.Synthesis of DOTA-conjugated multimeric [Tyr3]octreotide peptides via a combination of Cu(I)-catalyzed "click" cycloaddition and thio acid/sulfonyl azide "sulfo-click" amidation and their in vivo evaluation.Proteome-wide profiling of protein assemblies by cross-linking mass spectrometry.Synthesis and biological activity of N-terminal lipidated and/or fluorescently labeled conjugates of astressin as corticotropin releasing factor antagonists.Synthesis of nisin AB dicarba analogs using ring-closing metathesis: influence of sp(3) versus sp(2) hybridization of the α-carbon atom of residues dehydrobutyrine-2 and dehydroalanine-5 on the lipid II binding affinity.Preparation of novel alkylated arginine derivatives suitable for click-cycloaddition chemistry and their incorporation into pseudosubstrate- and bisubstrate-based kinase inhibitors.Lipid dependence of membrane anchoring properties and snorkeling behavior of aromatic and charged residues in transmembrane peptides.Influence of hydrophobic mismatch and palmitoylation on the association of transmembrane alpha-helical peptides with detergent-resistant membranes.Ring-closing metathesis for the synthesis of side chain knotted pentapeptides inspired by vancomycin.Strength of integration of transmembrane alpha-helical peptides in lipid bilayers as determined by atomic force spectroscopy.Influence of flanking residues on tilt and rotation angles of transmembrane peptides in lipid bilayers. A solid-state 2H NMR study.Pre-organization induced synthesis of a crossed alkene-bridged nisin Z DE-ring mimic by ring-closing metathesis.Versatile conjugation of octreotide to dendrimers by cycloaddition ("click") chemistry to yield high-affinity multivalent cyclic Peptide dendrimers.Enzymatic synthesis of C-terminal arylamides of amino acids and peptides.Synthesis and structural characterization of the individual diastereoisomers of a cross-stapled alkene-bridged nisin DE-ring mimic.Scalable purification of the lantibiotic nisin and isolation of chemical/enzymatic cleavage fragments suitable for semi-synthesis.A synergistic effect between cholesterol and tryptophan-flanked transmembrane helices modulates membrane curvature.pH-controlled aggregation polymorphism of amyloidogenic Aβ(16-22): insights for obtaining peptide tapes and peptide nanotubes, as function of the N-terminal capping moiety.Self-association of transmembrane alpha-helices in model membranes: importance of helix orientation and role of hydrophobic mismatch.Delayed fibril formation of amylin(20-29) by incorporation of alkene dipeptidosulfonamide isosteres obtained by solid phase olefin cross metathesis.Interfacial properties of the M1 segment of the nicotinic acetylcholine receptor.Self-assembly of amylin(20-29) amide-bond derivatives into helical ribbons and peptide nanotubes rather than fibrils.Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density.Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative.Inhibition of Octreotide Acylation Inside PLGA Microspheres by Derivatization of the Amines of the Peptide with a Self-Immolative Protecting Group.Semi-synthesis of biologically active nisin hybrids composed of the native lanthionine ABC-fragment and a cross-stapled synthetic DE-fragment.An electrostatic/hydrogen bond switch as the basis for the specific interaction of phosphatidic acid with proteinsProbing membrane protein orientation and structure using fast magic-angle-spinning solid-state NMRLooped Structure of Flowerlike Micelles Revealed by1H NMR Relaxometry and Light ScatteringSelective enrichment of Ser-/Thr-phosphorylated peptides in the presence of Ser-/Thr-glycosylated peptides
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P50
description
Forscher
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investigador
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researcher
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wetenschapper
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հետազոտող
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研究者
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name
Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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type
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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prefLabel
Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
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Dirk T.S. Rijkers
@nl
P1153
6701682781
P21
P31
P496
0000-0002-8874-7576