about
Dynamic Regulation of Quaternary Organization of the M1 Muscarinic Receptor by Subtype-selective Antagonist Drugs.Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targetingRegulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysisAnti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy.Dimerization of alpha1-adrenoceptors.The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice.The pharmacology of TUG-891, a potent and selective agonist of the free fatty acid receptor 4 (FFA4/GPR120), demonstrates both potential opportunity and possible challenges to therapeutic agonismPredicting small molecule fluorescent probe localization in living cells using QSAR modeling. 1. Overview and models for probes of structure, properties and function in single cells.Multiple AMPK activators inhibit l-carnitine uptake in C2C12 skeletal muscle myotubes.The orexin OX(1) receptor exists predominantly as a homodimer in the basal state: potential regulation of receptor organization by both agonist and antagonist ligands.Developing chemical genetic approaches to explore G protein-coupled receptor function: validation of the use of a receptor activated solely by synthetic ligand (RASSL).Ligand-induced internalization of the orexin OX(1) and cannabinoid CB(1) receptors assessed via N-terminal SNAP and CLIP-tagging.Ligand regulation of the quaternary organization of cell surface M3 muscarinic acetylcholine receptors analyzed by fluorescence resonance energy transfer (FRET) imaging and homogeneous time-resolved FRETSr2+ can become incorporated into an agonist-sensitive, cytoplasmic Ca2+ store in a cell line derived from the equine sweat gland epithelium.P2Y receptor-mediated Ca2+ signalling in cultured rat aortic smooth muscle cells.Novel role for proteinase-activated receptor 2 (PAR2) in membrane trafficking of proteinase-activated receptor 4 (PAR4).Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation.The protein kinase C inhibitor, Ro-31-7459, is a potent activator of ERK and JNK MAP kinases in HUVECs and yet inhibits cyclic AMP-stimulated SOCS-3 gene induction through inactivation of the transcription factor c-Jun.Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor.A Molecular Basis for Selective Antagonist Destabilization of Dopamine D3 Receptor Quaternary Organization.Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2.High-affinity interactions between human alpha1A-adrenoceptor C-terminal splice variants produce homo- and heterodimers but do not generate the alpha1L-adrenoceptor.Spatial Intensity Distribution Analysis: Studies of G Protein-Coupled Receptor Oligomerisation.Visualization of the activation of the histamine H3 receptor (H3R) using novel Fluorescence Resonance Energy Transfer Biosensors and their potential application to the study of H3R pharmacology.Amiloride impairs the cholinergic regulation of potassium permeability in the human sweat gland but not in the rat submandibular glandThe cholinergic regulation of potassium (86Rb+) permeability in sweat glands isolated from patients with cystic fibrosisThe effects of removing external sodium upon the control of potassium (86Rb+) permeability in the isolated human sweat glandPotassium (86Rb+) efflux from the rat submandibular gland under sodium-free conditions in vitroThe effect of a phorbol ester upon the cholinergic regulation of potassium permeability in the rat submandibular glandWhy fluorescent probes for endoplasmic reticulum are selective: an experimental and QSAR-modelling studyA general method to quantify ligand-driven oligomerization from fluorescence-based images
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
John D Pediani
@ast
John D Pediani
@en
John D Pediani
@es
John D Pediani
@nl
type
label
John D Pediani
@ast
John D Pediani
@en
John D Pediani
@es
John D Pediani
@nl
prefLabel
John D Pediani
@ast
John D Pediani
@en
John D Pediani
@es
John D Pediani
@nl
P106
P1153
6701812528
P31
P496
0000-0001-6615-537X