about
Applications of in vivo imaging in the evaluation of the pathophysiology of viral and bacterial infections and in development of countermeasures to BSL3/4 pathogensIntegrating high-content imaging and chemical genetics to probe host cellular pathways critical for Yersinia pestis infectionIdentification of small molecule inhibitors of anthrax lethal factorBacterial genome engineering and synthetic biology: combating pathogensHeat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imagingPhosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based AssaysBiochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins.In vivo oligomerization and raft localization of Ebola virus protein VP40 during vesicular budding.Tumor protease-activated, pore-forming toxins from a combinatorial library.A high-content imaging assay for the quantification of the Burkholderia pseudomallei induced multinucleated giant cell (MNGC) phenotype in murine macrophages.Synthesis and antibacterial evaluation of new, unsymmetrical triaryl bisamidine compounds.Protection against filovirus diseases by a novel broad-spectrum nucleoside analogue BCX4430.Identification of an antioxidant small-molecule with broad-spectrum antiviral activity.Pore-forming proteins and their application in biotechnology.Gene transfer: manipulating and monitoring function in cells and tissues.A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.Host response during Yersinia pestis infection of human bronchial epithelial cells involves negative regulation of autophagy and suggests a modulation of survival-related and cellular growth pathways.Alveolar macrophages infected with Ames or Sterne strain of Bacillus anthracis elicit differential molecular expression patterns.Molecular mechanisms of filovirus cellular trafficking.A high content imaging assay for identification of Botulinum neurotoxin inhibitorsSRC family kinase inhibitors antagonize the toxicity of multiple serotypes of botulinum neurotoxin in human embryonic stem cell-derived motor neuronsCharacterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species.High-throughput screen using a single-cell tyrosine phosphatase assay reveals biologically active inhibitors of tyrosine phosphatase CD45.A limited structural modification results in a significantly more efficacious diazachrysene-based filovirus inhibitorPeptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.L1000CDS2: LINCS L1000 characteristic direction signatures search engineSizing the Bacillus anthracis PA63 channel with nonelectrolyte poly(ethylene glycols)BCX4430 - A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease.Potent and broad-spectrum antibacterial activity of indole-based bisamidine antibiotics: synthesis and SAR of novel analogs of MBX 1066 and MBX 1090.Evaluation of Ebola Virus Inhibitors for Drug Repurposing.A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection.Anti-Ebola Activity of Diazachrysene Small Molecules.Induced IL-10 splice altering approach to antiviral drug discovery.Development of high-content imaging assays for lethal viral pathogens.Analysis of Ebola virus and VLP release using an immunocapture assay.Conformational sampling of the botulinum neurotoxin serotype A light chain: implications for inhibitor binding.An all-atom model of the pore-like structure of hexameric VP40 from Ebola: structural insights into the monomer-hexamer transition.Pore formation is not associated with macroscopic redistribution of P2X7 receptors.Rational design of small molecules as vaccine adjuvants.Novel therapeutic strategies to selectively kill cancer cells.
P50
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P50
description
researcher
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wetenschapper
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հետազոտող
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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Rekha G Panchal
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P106
P1153
6603807144
P31
P496
0000-0001-8621-9078