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Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway.Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Genotoxic Klebsiella pneumoniae in Taiwan.Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.Escherichia coli producing colibactin triggers premature and transmissible senescence in mammalian cells.Colibactin: understanding an elusive gut bacterial genotoxin.Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.Oral tolerance failure upon neonatal gut colonization with Escherichia coli producing the genotoxin colibactinThe Microbes inside Us and the Race for Colibactin.The colibactin warhead crosslinks DNA.The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic InfectionThe bacterial genotoxin colibactin promotes colon tumor growth by modifying the tumor microenvironmentClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.Colibactin Contributes to the Hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in Mouse Meningitis Infections.Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway.The Enterobacterial Genotoxins: Cytolethal Distending Toxin and Colibactin.Interplay between siderophores and colibactin genotoxin in Escherichia coli.MATE transport of the E. coli-derived genotoxin colibactin.High iron supply inhibits the synthesis of the genotoxin colibactin by pathogenic Escherichia coli through a non-canonical Fur/RyhB-mediated pathway.The Bacterial Stress-Responsive Hsp90 Chaperone (HtpG) Is Required for the Production of the Genotoxin Colibactin and the Siderophore Yersiniabactin in Escherichia coli.Small-molecule inhibitors prevent the genotoxic and protumoural effects induced by colibactin-producing bacteria.Iron Homeostasis Regulates the Genotoxicity of Escherichia coli That Produces Colibactin.In vivo evidence for a prodrug activation mechanism during colibactin maturation.A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicity.An adherent mucus layer attenuates the genotoxic effect of colibactin.Cytotoxic Escherichia coli strains encoding colibactin colonize laboratory mice.A Mechanistic Model for Colibactin-Induced Genotoxicity.Cytotoxic Escherichia coli strains encoding colibactin and cytotoxic necrotizing factor (CNF) colonize laboratory macaques.Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis.ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.Biosynthesis: SAM cycles up for colibactin.Cytotoxic Escherichia coli strains encoding colibactin isolated from immunocompromised mice with urosepsis and meningitis.Colibactin: More Than a New Bacterial Toxin.The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.Expression analysis of the colibactin gene cluster coding for a novel polyketide in Escherichia coli.
P921
Q30967654-4EE9D2A3-612C-4B2C-BA26-08F477BA367CQ33365728-CA8BB215-092D-4805-A2E1-E43410318D75Q33650052-1878d611-41bc-b866-437e-2ef08979bb44Q33879227-D403E826-2282-406C-8A44-44F82EC0232CQ34377079-5F7D90C8-88B7-49E7-BCDD-2ACE27B7D555Q34495096-1BE3962C-7492-48B0-8F45-A3A54A53B3FDQ35024032-5501482A-D20E-420F-A470-D47A923BCA9AQ35609329-EEC6AE87-700A-4F3D-8080-73130DD9C00EQ35694112-1095E7DA-69FE-472D-B2E3-50A9A862A0FEQ35844576-38B8693D-F801-4719-B5CC-061DE026F167Q35947396-60A5FA90-E06F-48A8-9A6C-15A340CAA1DEQ36192061-589F5F3F-1AE7-4B40-965E-94E4DD0D8EB2Q36219549-59818440-1524-4328-A16A-A2A8D6999960Q37410263-6BC5E69B-47D9-4D57-A1A9-DBFC819ACB63Q37730929-D10AE1A1-2B0E-430B-9BE6-54B54C37FEF3Q38605864-CD578FBA-C018-4D41-824B-F3DAD837E6ADQ38897671-3D850196-CFA8-4F8B-9A40-585B58F14215Q39179762-CE567550-3020-4A18-B0C2-C4E3189A8808Q39443565-07388000-3E18-4987-9C35-DADC37A66F05Q40163516-5A89F2D0-C048-4AF3-90F4-D97772ADD91CQ40614480-8B49FDC5-7B88-4774-974C-7FB094029782Q41583397-82EA9684-24B4-4745-A77B-02805F5B1B3DQ41903092-6B8E4C0F-A4C8-401A-8866-C81134270EC2Q44140961-2081A709-88CD-40E3-8D61-738132CED75DQ45678137-D28CC1C1-DC5D-4004-AF4C-A12B9A97151EQ46257981-050C841E-A210-4059-83F4-3959483DB569Q46767462-D3838072-B0CA-4748-8CA3-0FCE1C4ACD26Q46773646-03B2D772-5A2F-4BCE-9ABE-68A2B0E44ED8Q47149945-4F61BE20-5E54-416E-AE77-DDDF4A0C6EEAQ47263315-E55E6F41-D532-4C4C-90C0-C48C3192ECE2Q48190463-71B1202C-A475-4FA7-8A99-746ED42B9E8CQ48349705-BEE48351-71A8-40FF-A4F4-E3977BA34863Q50020267-4F18E854-50DA-44BC-AD71-0766BE09CF69Q51783462-665CEB7F-9058-453C-884F-2E8240BD23B7Q52593550-67912FD2-A8AB-4118-A6C5-8687D228AEA2Q52646141-33ED0860-647F-4F5E-B6B1-9EAF302B13AFQ53068393-09777684-3FE0-4EB7-B1DC-1D2DD1CDCAF1Q54272417-DEF6B1C6-4D3C-4B17-A84F-6B8646727E65Q54292519-05A9A1F7-DB58-424D-AA69-51D05BC820CFQ54435829-C78BD633-8FDF-442B-B2A3-D081183CC31B
P921
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
colibactin
@en
type
label
colibactin
@en
prefLabel
colibactin
@en
P662
P2017
C12(CC2)NC(=O)C(C2=N[C@@H](C)C ...... 2(CC2)NC(=O)C=1C1CC[C@H](C)N=1
P234
1S/C37H38N8O7S2/c1-17-3-5-21(4 ...... 44,51)(H,45,52)/t17-,18-/m0/s1
P235
ZWKHDAZPVITMAI-ROUUACIJSA-N
P274
C₃₇H₃₈N₈O₇S₂