Structural basis for the potent and selective inhibition of casein kinase 1 epsilonEntrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymesIC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases.Csnk1e is a genetic regulator of sensitivity to psychostimulants and opioids.Casein kinase 1δ activity: a key element in the zebrafish circadian timing system.Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period.Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra.Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization.
P921
Q27683092-3DDCBA18-D4C2-4AD0-A10D-B5ED770F0058Q28290094-9720E6A1-273D-47B2-A71E-CDF682097D4EQ30500880-3F1CBE75-1D5C-4546-BCFF-C6CBC37F3C67Q34122676-D7A6A9C5-23A3-4DB6-92FC-39ED7F7EEF3FQ34233183-1BDC6F3A-5C30-454A-965A-A78234B8007AQ34562728-6C14FCE1-BEC3-4B5B-B0AC-8CD34ED2705BQ34982171-5C00C170-63D0-407A-BBAD-F7420B285426Q37223289-0857E877-6E20-45CD-996E-B580DF9B740EQ42716122-AF454BF2-9F53-4F4F-A2E3-61BB4B283B40
P921
description
chemesch Verbindung
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chemical compound
@en
chemical compound
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chemical compound
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chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
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name
PF-4800567
@en
PF-4800567
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PF-4800567
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label
PF-4800567
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PF-4800567
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PF-4800567
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PF-480
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PF4800567
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PF-4800567
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PF-4800567
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PF-4800567
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P592
P661
P662
P683
P1579
P2067
P231
1188296-52-7
P233
C1COCCC1N2C3=C(C(=N2)COC4=CC(=CC=C4)Cl)C(=NC=N3)N
P234
1S/C17H18ClN5O2/c18-11-2-1-3-1 ...... 8,10,12H,4-7,9H2,(H2,19,20,21)
P235
AUMDBEHGJRZSOO-UHFFFAOYSA-N
P274
C₁₇H₁₈ClN₅O₂
P3117
DTXSID20703849
P592
CHEMBL2069623