about
Ectopic expression of MHC class II genes (RT1.B(I) beta/alpha) in rat hepatocytes in vivo and in culture can be elicited by treatment with the pregnane X receptor agonists pregnenolone 16 alpha-carbonitrile and dexamethasoneA pregnane X receptor agonist with unique species-dependent stereoselectivity and its implications in drug development.Evaluation of computational docking to identify pregnane X receptor agonists in the ToxCast database.Conicasterol E, a small heterodimer partner sparing farnesoid X receptor modulator endowed with a pregnane X receptor agonistic activity, from the marine sponge Theonella swinhoei.Pregnane X receptor agonists enhance intestinal epithelial wound healing and repair of the intestinal barrier following the induction of experimental colitis.Pregnane X receptor agonists impair postprandial glucose tolerance.Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A.Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays.
P921
Q28576186-0E3CDDB2-C463-4977-9927-0922A1034DD5Q31169645-4671ADEB-E615-42ED-8441-B33233BA746DQ34215650-E617B2D0-5C97-479C-95B3-5729F43E6645Q39435827-C85A86F2-148D-4260-B541-5D2CDB1586CAQ42230149-5147385E-A7B0-41F9-8B85-3C92534337B0Q42595219-A972CC07-4ACD-4FF8-9BC4-DE2C783FCA7FQ42701036-8021EE58-1FEA-4E8E-ABFB-336D89ED520EQ42790667-756CEEEE-BB45-4D85-848A-FE66910A13E3
P921
description
class of chemical compounds with an agonist activity against the pregnane X receptor
@en
name
pregnane X receptor agonist
@en
type
label
pregnane X receptor agonist
@en
prefLabel
pregnane X receptor agonist
@en