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High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationshipsIdentification of oxadiazoles as new drug leads for the control of schistosomiasisCompound Management for Quantitative High-Throughput ScreeningIdentification of small-molecule inhibitors of Zika virus infection and induced neural cell death via a drug repurposing screenRecent developments in the use of differential scanning fluorometry in protein and small molecule discovery and characterizationThe Tox21 robotic platform for the assessment of environmental chemicals--from vision to realityComprehensive Mechanistic Analysis of Hits from High-Throughput and Docking Screens against β-LactamaseDiscovery of a 2,4-Diamino-7-aminoalkoxyquinazoline as a Potent and Selective Inhibitor of Histone Lysine Methyltransferase G9aIdentification and Optimization of Inhibitors of Trypanosomal Cysteine Proteases: Cruzain, Rhodesain, and TbCatBMolecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124Complementarity Between a Docking and a High-Throughput Screen in Discovering New Cruzain InhibitorsQuantitative High-Throughput Screening Identifies 8-Hydroxyquinolines as Cell-Active Histone Demethylase InhibitorsFirefly Luciferase in Chemical Biology: A Compendium of Inhibitors, Mechanistic Evaluation of Chemotypes, and Suggested Use As a ReporterPeroxiredoxin-1 from the Human Hookworm Ancylostoma ceylanicum Forms a Stable Oxidized Decamer and Is Covalently Inhibited by Conoidin ACell-based assays to support the profiling of small molecules with histone methyltransferase and demethylase modulatory activityInduced Pluripotent Stem Cell Models to Enable In Vitro Models for Screening in the Central Nervous SystemQuantitative high-throughput screen identifies inhibitors of the Schistosoma mansoni redox cascadeIdentification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1A high-throughput approach for identification of novel general anestheticsDifferential scanning fluorometry signatures as indicators of enzyme inhibitor mode of action: case study of glutathione S-transferaseHigh-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin bindingA comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κDiverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collectionDiscovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapyA panel of diverse assays to interrogate the interaction between glucokinase and glucokinase regulatory protein, two vital proteins in human diseaseA high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2Novel Phenotypic Outcomes Identified for a Public Collection of Approved Drugs from a Publicly Accessible Panel of AssaysMethod for Assaying the Lipid Kinase Phosphatidylinositol-5-phosphate 4-kinase α in Quantitative High-Throughput Screening (qHTS) Bioluminescent FormatA High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell ModelsHigh-throughput fluorescence imaging approaches for drug discovery using in vitro and in vivo three-dimensional modelsCurrent approaches for the discovery of drugs that deter substance and drug abuse.AlphaScreen-Based Assays: Ultra-High-Throughput Screening for Small-Molecule Inhibitors of Challenging Enzymes and Protein-Protein InteractionsAllosteric inhibitors of the Eya2 phosphatase are selective and inhibit Eya2-mediated cell migration.High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.Quantitative analyses of aggregation, autofluorescence, and reactivity artifacts in a screen for inhibitors of a thiol proteaseA potent and selective inhibitor targeting human and murine 12/15-LOX.High-throughput identification of promiscuous inhibitors from screening libraries with the use of a thiol-containing fluorescent probeAn Automated High-Throughput Metabolic Stability Assay Using an Integrated High-Resolution Accurate Mass Method and Automated Data Analysis SoftwareQuantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.Fluorescent protein-based cellular assays analyzed by laser-scanning microplate cytometry in 1536-well plate format.
P50
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P50
name
Anton Simeonov
@en
type
label
Anton Simeonov
@en
prefLabel
Anton Simeonov
@en