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about
P185
Are Oxazolidinones Really Unproductive, Parasitic Species in Proline Catalysis? – Thoughts and Experiments Pointing to an Alternative ViewChemical and Biological Investigations ofβ-OligoargininesGeneration and synthetic applications of 2-lithio-1,3-dithianesOn the influence of charged side chains on the folding-unfolding equilibrium of beta-peptides: a molecular dynamics simulation study.Imaging of a beta-peptide distribution in whole-body mice sections by MALDI mass spectrometry.On the mechanism of eukaryotic cell penetration by α- and β-oligoarginines--targeting infected erythrocytes.A novel beta-peptidyl aminopeptidase (BapA) from strain 3-2W4 cleaves peptide bonds of synthetic beta-tri- and beta-dipeptides.Helical content of a β(3)-octapeptide in methanol: molecular dynamics simulations explain a seeming discrepancy between conclusions derived from CD and NMR data.TADDOLs, Their Derivatives, and TADDOL Analogues: Versatile Chiral Auxiliaries.Permeation through phospholipid bilayers, skin-cell penetration, plasma stability, and CD spectra of α- and β-oligoproline derivatives.Bacterial beta-peptidyl aminopeptidases with unique substrate specificities for beta-oligopeptides and mixed beta,alpha-oligopeptides.Enzymatic degradation of beta- and mixed alpha,beta-oligopeptides.Enzyme-catalyzed formation of beta-peptides: beta-peptidyl aminopeptidases BapA and DmpA acting as beta-peptide-synthesizing enzymes.The fourth helical secondary structure of beta-peptides: the (P)-28-helix of a beta-hexapeptide consisting of (2R,3S)-3-amino-2-hydroxy acid residues.Beta2-amino acids-syntheses, occurrence in natural products, and components of beta-peptides1,2.Helices and other secondary structures of beta- and gamma-peptides.The world of beta- and gamma-peptides comprised of homologated proteinogenic amino acids and other components.Joy and flustration with organofluorine compounds - a fluorous autobiography.A journey from the pool of chiral synthetic building blocks to cell-penetrating peptides, to a novel type of enzyme - and back.Beta-peptidic peptidomimetics.Visible-Light Microscopic Discovery of Up to 150 μm Long Helical Amyloid Fibrils Built of the Dodecapeptide H-(Val-Ala-Leu)4 -OH and of Decapeptides Derived from Insulin.On the terminal homologation of physiologically active peptides as a means of increasing stability in human serum--neurotensin, opiorphin, B27-KK10 epitope, NPY.ADME investigations of unnatural peptides: distribution of a 14C-labeled beta 3-octaarginine in rats.pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains.Interaction of β(3) /β(2) -peptides, consisting of Val-Ala-Leu segments, with POPC giant unilamellar vesicles (GUVs) and white blood cancer cells (U937)--a new type of cell-penetrating peptides, and a surprising chain-length dependence of their vesiProbing the interactions of an acyl carrier protein domain from the 6-deoxyerythronolide B synthase.Comparative metabolism of alpha- and beta-peptides in the insect Heliothis virescens and in plant cells of black Mexican sweet maize.Improved efficacy of fosmidomycin against Plasmodium and Mycobacterium species by combination with the cell-penetrating peptide octaarginine.Cellular uptake studies with beta-peptides.Structure-based evolution of subtype-selective neurotensin receptor ligands.Reaction of Fe3(CO)12 with octreotide--chemical, electrochemical and biological investigations.A theoretical and experimental study of the effects of silyl substituents in enantioselective reactions catalyzed by diphenylprolinol silyl ether.Syntheses, receptor bindings, in vitro and in vivo stabilities and biodistributions of DOTA-neurotensin(8-13) derivatives containing β-amino acid residues - a lesson about the importance of animal experiments.cis-Stilbene and (1 alpha,2 beta,3 alpha)-(2-ethenyl-3-methoxycyclopropyl)benzene as mechanistic probes in the Mn(III)(salen)-catalyzed epoxidation: influence of the oxygen source and the counterion on the diastereoselectivity of the competitive conBeta(2)/beta(3)-di- and alpha/beta(3)-tetrapeptide derivatives as potent agonists at somatostatin sst(4) receptors.Chiral hydroperoxides as oxygen source in the catalytic stereoselective epoxidation of allylic alcohols by sandwich-type polyoxometalates: control of enantioselectivity through a metal-coordinated template.Design, synthesis and structural investigations of a beta-peptide forming a 314-helix stabilized by electrostatic interactions.Probing the proteolytic stability of beta-peptides containing alpha-fluoro- and alpha-hydroxy-beta-amino acids.Preparation and characterization of TADDOLs immobilized on hydrophobic controlled-pore-glass silica gel and their use in enantioselective heterogeneous catalysis.Gamma2-, gamma3-, and gamma(2,3,4)-amino acids, coupling to gamma-hexapeptides: CD spectra, NMR solution and X-ray crystal structures of gamma-peptides.
P50
description
Duits scheikundige
@nl
German chemist
@en
German chemist
@en-ca
German chemist
@en-gb
Saksamaa keemik
@et
ceimiceoir Gearmánach
@ga
chimist german
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chimiste allemand
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deutscher Chemiker
@de
kimist gjerman
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name
Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
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Dieter Seebach
@es
Dieter Seebach
@fr
Dieter Seebach
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Dieter Seebach
@nb
Dieter Seebach
@nds