The eleventh edition of the Caribbean Series (Serie del Caribe) was played in 1959. It was held from February 10 through February 15 with the champions teams from Cuba (Almendares), Panama (Coclé), Puerto Rico (Santurce) and Venezuela (Oriente). The format consisted of 12 games, each team facing the other teams twice. The games were played at UCV Stadium in Caracas, Venezuela, which boosted capacity to 35.000 seats, and the first pitch was thrown by Edgar Sanabria, by then the President of Venezuela.