A-796,260
A-796,260 is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids with the 3-tetramethylcyclopropylmethanone group, imparts significant selectivity for CB2, and A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1. It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects.
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A-796,260
A-796,260 is a drug developed by Abbott Laboratories that acts as a potent and selective cannabinoid CB2 receptor agonist. Replacing the aromatic 3-benzoyl or 3-naphthoyl group found in most indole derived cannabinoids with the 3-tetramethylcyclopropylmethanone group, imparts significant selectivity for CB2, and A-796,260 was found to be a highly selective CB2 agonist with little affinity for CB1, having a CB2 Ki of 4.6 nM vs 945 nM at CB1. It has potent analgesic and anti-inflammatory actions in animal models, being especially effective in models of neuropathic pain, but without producing cannabis-like behavioral effects.
has abstract
A-796,260 is a drug developed ...... nabis-like behavioral effects.
@en
CAS number
895155-26-7
ChEMBL
FDA UNII code
5N69DXA53Z
PubChem
Wikipage page ID
30,411,492
page length (characters) of wiki page
Wikipage revision ID
984,224,519
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CAS number
ChEMBL
ChemSpiderID
IUPAC name
[1--1H-indol-3-yl]-methanone
@en
legal UK
Class B
@en
PubChem
11,584,525
SMILES
C4COCCN4CCncc1CC2CC2C
@en
StdInChIKey
ZCFHOMLAFTWDFM-UHFFFAOYSA-N
@en
Verifiedfields
changed
@en
verifiedrevid
456,505,609
Watchedfields
changed
@en
wikiPageUsesTemplate
hypernym
comment
A-796,260 is a drug developed ...... nabis-like behavioral effects.
@en
label
A-796,260
@en