MN-25
MN-25 (UR-12) is a drug invented by Bristol-Myers Squibb, that acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM, but 22x lower affinity for the psychoactive CB1 receptors with a Ki of 245 nM. The indole 2-methyl derivative has the ratio of affinities reversed however, with a Ki of 8 nM at CB1 and 29 nM at CB2, which contrasts with the usual trend of 2-methyl derivatives having increased selectivity for CB2 (cf. JWH-018 vs JWH-007, JWH-081 vs JWH-098).
primaryTopic
MN-25
MN-25 (UR-12) is a drug invented by Bristol-Myers Squibb, that acts as a reasonably selective agonist of peripheral cannabinoid receptors. It has moderate affinity for CB2 receptors with a Ki of 11 nM, but 22x lower affinity for the psychoactive CB1 receptors with a Ki of 245 nM. The indole 2-methyl derivative has the ratio of affinities reversed however, with a Ki of 8 nM at CB1 and 29 nM at CB2, which contrasts with the usual trend of 2-methyl derivatives having increased selectivity for CB2 (cf. JWH-018 vs JWH-007, JWH-081 vs JWH-098).
has abstract
MN-25 (UR-12) is a drug invent ...... rboxamide cannabinoid ligands.
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CAS number
501926-82-5
501927-29-3
ChEMBL
FDA UNII code
8WXU5YRE25
PubChem
Wikipage page ID
33,525,378
page length (characters) of wiki page
Wikipage revision ID
991,819,413
Link from a Wikipage to another Wikipage
CAS number
ChEMBL
ChemSpiderID
26,286,811
index2 label
IUPAC name
legal CA
Schedule II
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legal DE
NpSG
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legal UK
Class B
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PubChem
71,308,243
SMILES
COC1=CC3=CC=C1
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StdInChIKey
VQGDMQICNRCQEH-UFKXBGGNSA-N
@en
synonyms
N-[-Fenchyl]-1-[2-ethyl]-7-methoxyindole-3-carboxamide
@en
verifiedrevid
459,128,585
wikiPageUsesTemplate
comment
MN-25 (UR-12) is a drug invent ...... JWH-007, JWH-081 vs JWH-098).
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label
MN-25
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