AB-001
AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1. The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which posse
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1-pentyl-3-(1-adamantoyl)indole4-HTMPIPOA-834,735AB-005AM-1248AdamantaneC24H31NODesigner drugDrugs controlled by the German BetäubungsmittelgesetzLiebermann reagentList of designer drugsList of miscellaneous designer cannabinoidsList of psychedelic drugsMAM-2201MN-25STS-135 (drug)Structural scheduling of synthetic cannabinoidsUR-144
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AB-001
AB-001 (1-pentyl-3-(1-adamantoyl)indole) is a designer drug that was found as an ingredient in synthetic cannabis smoking blends in Ireland in 2010 and Hungary and Germany in 2011. It is unclear who AB-001 was originally developed by, but it is structurally related to compounds such as AM-1248 and its corresponding 1-(tetrahydropyran-4-ylmethyl) analogue, which are known to be potent cannabinoid agonists with moderate to high selectivity for CB2 over CB1. The first published synthesis and pharmacological evaluation of AB-001 revealed that it acts as a full agonist at CB1 (EC50 = 35 nM) and CB2 receptors (EC50 = 48 nM). However, AB-001 was found to possess only weak cannabimimetic effects in rats at doses up to 30 mg/kg, making it less potent than the carboxamide analogue APICA, which posse
has abstract
AB-001 (1-pentyl-3-(1-adamanto ...... activity at doses of 3 mg/kg.
@en
CAS number
1345973-49-0
FDA UNII code
H657DIA015
PubChem
Wikipage page ID
33,362,332
page length (characters) of wiki page
Wikipage revision ID
991,876,184
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CAS number
ChemSpiderID
26,286,891
IUPAC name
legal CA
Schedule II
@en
legal DE
Anlage II
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legal UK
Class B
@en
PubChem
57,404,070
SMILES
CCCCCn1ccCC34CC5CCCCC4
@en
StdInChIKey
SHWDYCMMUPPWQM-UHFFFAOYSA-N
@en
UNII
H657DIA015
@en
Verifiedfields
changed
@en
verifiedrevid
460,440,720
Watchedfields
changed
@en
wikiPageUsesTemplate
hypernym
comment
AB-001 (1-pentyl-3-(1-adamanto ...... de analogue APICA, which posse
@en
label
AB-001
@en