Amino acid N-carboxyanhydrides, also called Leuchs' anhydrides, are reactive derivatives of amino acids. They are used in the field of biomaterials for their applications in drug delivery, gene therapy, antibiotics, and tissue engineering. Typically, these compounds are derived from amino acids by treatment with triphosgene, phosgene, PCl5, and other halogenating reagents. NCAs can be used to prepare polypeptides through ring-opening polymerization, a practical approach for large-scale production of polypeptides where sequence specificity is less important than bulk physical properties. These compounds find application in biochemistry, biomedical engineering, and nanotechnology due to their propensity for polymerization upon treatment with nucleophiles, hexamethyldisilazane, and transition