Comarca de Guijuelo is a comarca in the province of Salamanca, Castile and León. It contains the following subcomarcas: * Entresierras, which contains the municipalities of Casafranca, Endrinal, Frades de la Sierra, Herguijuela, La Sierpe, Los Santos, Membribe de la Sierra and Monleón. * Salvatierra, which contains the municipalities of Aldeavieja de Tormes, Berrocal, Fuenterroble, Guijuelo, Montejo, Pedrosillo de los Aires, Pizarral and Salvatierra de Tormes. * Alto Tormes, which contains the municipalities of Cespedosa de Tormes, Gallegos de Solmirón, Navamorales, Puente del Congosto, El Tejado, Guijo de Ávila and La Tala.