Manuel Rodrigues de Lamego (born circa 1590) was a Portuguese-born merchant and slave trader active in Europe, Africa, Asia and the Americas. Rodrigues de Lamego was a Marrano. He was contracted by the Spanish Empire with an official asiento to provide their colonies in the Spanish Americas with African slaves from 1 April 1623 to 25 September 1631. During this time, he was the Contratodore (monopolist trader) for the Atlantic slave trade in Angola's Portuguese West African territory. Contrary to his predecessor as asiento holder, António Fernandes de Elvas, he was not the Contratodore for Cape Verde and Guinea. After his tenure, he was succeeded as asiento holder by and , while he was succeeded as Contratodore for Angola by .