Parkin (ligase)
Parkin is a 465-residue E3 ubiquitin ligase that plays a critical role in ubiquitination- the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes. Ubiquitination involves the sequential action of three enzymes. First, an E1 ubiquitin-activating enzyme binds to inactive Ub in eukaryotic cells via a thioester bond and mobilises it in an ATP-dependent process. Ub is then transferred to an E2 ubiquitin-conjugating enzyme before being conjugated to the target protein via an E3 ubiquitin ligase. There exists a multitude of E3 ligases, which differ in structure and substrate specificity to allow selective targeting of proteins to intracellular degradation.
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ACSL1ACSL4AR-JPAggresomeAlpha-synucleinAr-jpAutophagyBCL2L2Buruli ulcerCASKCauses of Parkinson's diseaseChromosomal fragile siteChromosome 6DiGeorge syndromeEndoplasmic-reticulum-associated protein degradationFBXO7FBXW7GPR37HK1HSPA1AHSPA1LHSPA8Helen WaldenHistory of Parkinson's diseaseLPRS2LRRK2LeprosyList of OMIM disorder codesList of human protein-coding genes 3Lprs2Miratul MuqitMitophagyMultisynthetase complex auxiliary component p38NeurogeneticsOzzy OsbournePARK2PARK2 (gene)PDCD2PINK1PRKN
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Parkin (ligase)
Parkin is a 465-residue E3 ubiquitin ligase that plays a critical role in ubiquitination- the process whereby molecules are covalently labelled with ubiquitin (Ub) and directed towards degradation in proteasomes or lysosomes. Ubiquitination involves the sequential action of three enzymes. First, an E1 ubiquitin-activating enzyme binds to inactive Ub in eukaryotic cells via a thioester bond and mobilises it in an ATP-dependent process. Ub is then transferred to an E2 ubiquitin-conjugating enzyme before being conjugated to the target protein via an E3 ubiquitin ligase. There exists a multitude of E3 ligases, which differ in structure and substrate specificity to allow selective targeting of proteins to intracellular degradation.
has abstract
La parkine est une enzyme de t ...... ué sur le chromosome 6 humain.
@fr
PRKN (англ. Parkin RBR E3 ubiq ...... ендоплазматичному ретикулумі.
@uk
Parkin is a 465-residue E3 ubi ...... metabolism in tumourigenesis.
@en
Parkin ist ein Enzym in Säuget ...... tochondrien rekrutiert werden.
@de
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La parkine est une enzyme de t ...... ué sur le chromosome 6 humain.
@fr
PRKN (англ. Parkin RBR E3 ubiq ...... : ВалінW: Триптофан Y: Тирозин
@uk
Parkin is a 465-residue E3 ubi ...... to intracellular degradation.
@en
Parkin ist ein Enzym in Säuget ...... ängt von weiteren Faktoren ab.
@de
label
PRKN
@uk
Parkin (ligase)
@en
Parkine
@fr
Ubiquitin-Protein-Ligase Parkin
@de