TGF beta signaling pathway
The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.
ACVRL1Activin type 1 receptorsActivin type 2 receptorsAdult stem cellAnti-Müllerian hormoneBMPR2Bone morphogenetic protein 2C3orf67Cerberus (protein)CriptoCytokine receptorDaf-1Daf-14Daf-3Daf-4Daf-5Daf-7Daf-8Death-associated protein 6EGLN1EndoglinExtranodal NK/T-cell lymphoma, nasal typeFAT1Glandular odontogenic cystGlycitinGremlin (protein)HMGA2Hereditary hemorrhagic telangiectasiaInduced stem cellsLefty (protein)List of signalling pathwaysMediator (coactivator)Mothers against decapentaplegic homolog 3Mothers against decapentaplegic homolog 4Nodal signaling pathwayNon-alcoholic fatty liver diseaseOsteoblastOutline of immunologyParacrine signalingR-SMAD
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TGF beta signaling pathway
The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression.
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En biochimie, la voie de signa ...... signalisation très dynamique.
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La vía de señalización del fac ...... de expresión de genes blanco.
@es
TGF-beta-signalvägen är en sig ...... av extracellulärt matrix, m.m.
@sv
The transforming growth factor ...... ion of target gene expression.
@en
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En biochimie, la voie de signa ...... signalisation très dynamique.
@fr
La vía de señalización del fac ...... otra proteína, la coSMAD SMAD
@es
TGF-beta-signalvägen är en sig ...... ndra signaltransduktionsvägar:
@sv
The transforming growth factor ...... ion of target gene expression.
@en
label
TGF beta signaling pathway
@en
TGF-beta-signalvägen
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Voie de signalisation des Smad
@fr
Vía de señalización del TGF-beta
@es