Abruzzo (Abruzzi) is an Italian wine region located in the mountainous central Italian region of Abruzzo along the Adriatic Sea. It is bordered by the Molise wine region to the south, Marche to the north and Lazio to the west. Abruzzo's rugged terrain, 65% of which is mountainous, help to isolate the region from the winemaking influence of the ancient Romans and Etruscans in Tuscany but the area has had a long history of wine production.