Casokefamide
Casokefamide (INN), also known as β-casomorphin 4027 (β-CM-4027) and [D-Ala2,4,Tyr5]-β-casomorphin-5-amide, is a peripherally-specific, synthetic opioid pentapeptide with the amino acid sequence Tyr-D-Ala-Phe-D-Ala-Tyr-NH2. Derived from the β-casomorphin sequence, it was designed with the intention of improving resistance to digestive enzymes so that it could be used as an antidiarrheal medicine. Unlike other casomorphins, which are generally selective μ-opioid receptor agonists, casokefamide binds to both the μ- and δ-opioid receptors. In a clinical study, casokefamide was found to be effective via the oral route for the treatment of chronic diarrhea, and did not produce any side effects. However, further clinical development was not pursued and it was never marketed.
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Casokefamide
Casokefamide (INN), also known as β-casomorphin 4027 (β-CM-4027) and [D-Ala2,4,Tyr5]-β-casomorphin-5-amide, is a peripherally-specific, synthetic opioid pentapeptide with the amino acid sequence Tyr-D-Ala-Phe-D-Ala-Tyr-NH2. Derived from the β-casomorphin sequence, it was designed with the intention of improving resistance to digestive enzymes so that it could be used as an antidiarrheal medicine. Unlike other casomorphins, which are generally selective μ-opioid receptor agonists, casokefamide binds to both the μ- and δ-opioid receptors. In a clinical study, casokefamide was found to be effective via the oral route for the treatment of chronic diarrhea, and did not produce any side effects. However, further clinical development was not pursued and it was never marketed.
has abstract
Casokefamide (INN), also known ...... ued and it was never marketed.
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CAS number
98815-38-4
ChEMBL
FDA UNII code
B453T1E8MP
PubChem
Wikipage page ID
35,631,023
page length (characters) of wiki page
Wikipage revision ID
963,741,883
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ATC prefix
None
@en
CAS number
ChEMBL
ChemSpiderID
IUPAC name
PubChem
SMILES
O=C[C@@H]Cc3ccccc3
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StdInChIKey
XDRHVZLDLNGKLM-FLVVDCEDSA-N
@en
synonyms
L-tyrosyl-D-alanyl-L-phenylalanyl-D-alanyl-L-tyrosinamide
@en
UNII
B453T1E8MP
@en
wikiPageUsesTemplate
hypernym
comment
Casokefamide (INN), also known ...... ued and it was never marketed.
@en
label
Casokefamide
@en