Diflomotecan
Diflomotecan (also known as BN80905) is a chemotherapeutic agent that is a topoisomerase inhibitor (Top1). It varies from other camptothecin based Top1 inhibitors like topotecan in having a 7-membered E-ring. The oxepan-2-one ring in the homocamptothecin analogues is more stable in plasma compared to the 6-membered lactone in camptothecin. Diflomotecan was the first homocamptothecin to enter clinical trials and is currently in phase I for treating patients with sensitive small cell lung cancer (SCLC).
primaryTopic
Diflomotecan
Diflomotecan (also known as BN80905) is a chemotherapeutic agent that is a topoisomerase inhibitor (Top1). It varies from other camptothecin based Top1 inhibitors like topotecan in having a 7-membered E-ring. The oxepan-2-one ring in the homocamptothecin analogues is more stable in plasma compared to the 6-membered lactone in camptothecin. Diflomotecan was the first homocamptothecin to enter clinical trials and is currently in phase I for treating patients with sensitive small cell lung cancer (SCLC).
has abstract
Diflomotecan (also known as BN ...... small cell lung cancer (SCLC).
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alternative name
Diflomotecan
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CAS number
220997-97-7
ChEBI
ChEMBL
FDA UNII code
QKT1LC4J1P
PubChem
Wikipage page ID
63,435,505
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Wikipage revision ID
963,838,041
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CAS number
ChEBI
ChEMBL
ChemSpiderID
IUPAC name
PubChem
SMILES
O=C1N2C=CC=C1COC5=O
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StdInChIKey
LFQCJSBXBZRMTN-OAQYLSRUSA-N
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tradename
Diflomotecan
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UNII
QKT1LC4J1P
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comment
Diflomotecan (also known as BN ...... small cell lung cancer (SCLC).
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label
Diflomotecan
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