Edward Holmes may refer to: * Edward Holmes (architect) (1832–1909), English architect * Edward Holmes (field hockey) (1880–?), Irish field hockey player and Olympic medalist * Edward Holmes (musicologist) (1797–1859), English musicologist and music critic * Edward Lorenzo Holmes (1828–1900), American ophthalmologist * Edward C. Holmes (born 1965), Australian evolutionary biologist and virologist * Edward Carleton Holmes (1843–1932), one of the solicitors who drew up the first rules of Rugby Football Union * Lefty Holmes, American baseball pitcher