Edwin Bret Hart (December 25, 1874 – March 12, 1953) was an American biochemist long associated with the University of Wisconsin-Madison. A native of Sandusky, Ohio, Hart studied physiological chemistry in Germany under Albrecht Kossel (recipient of the 1910 Nobel Prize in Physiology or Medicine) at the University of Marburg and University of Heidelberg. Upon his return to the United States, he worked at the New York State Agricultural Experiment Station (part of Cornell University) in Geneva, New York, and then at the University of Michigan before being hired in 1906 by Stephen M. Babcock of the University of Wisconsin to conduct what later came to be known as the "single-grain experiment", which ran from May 1907 to 1911. This experiment entailed a long-term feeding plan using a chemical