G beta-gamma complex
The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, and gamma subunits, or Gα, Gβ, and Gγ. When a G protein-coupled receptor (GPCR) is activated, Gα dissociates from Gβγ, allowing both subunits to perform their respective downstream signaling effects. One of the major functions of Gβγ is the inhibition of the Gα subunit.
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5-HT2A receptor5-Hydroxyeicosatetraenoic acid5-Oxo-eicosatetraenoic acidBeta-gamma complexCSTF1G-Beta-Gamma complexG-beta/G-gammaG12/G13 alpha subunitsGBGGGL domainGNA12GNA13GTPaseG alpha subunitG beta gammaG beta gamma subunitsG beta subunitG proteinG protein-coupled inwardly-rectifying potassium channelG protein-coupled receptorG protein-coupled receptor kinase 2G protein beta subunitGamma subunitGi alpha subunitGoLoco motifGq alpha subunitGrowth hormone–releasing hormoneGs alpha subunitHeterotrimeric G proteinLigand-gated ion channelMuscarinePLCE1Phospholipase CPhospholipase DPleckstrin homology domainProstacyclin receptorProstaglandin DP2 receptorProstaglandin EP1 receptorProstaglandin EP2 receptorProstaglandin EP3 receptor
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G beta-gamma complex
The G beta-gamma complex (Gβγ) is a tightly bound dimeric protein complex, composed of one Gβ and one Gγ subunit, and is a component of heterotrimeric G proteins. Heterotrimeric G proteins, also called guanosine nucleotide-binding proteins, consist of three subunits, called alpha, beta, and gamma subunits, or Gα, Gβ, and Gγ. When a G protein-coupled receptor (GPCR) is activated, Gα dissociates from Gβγ, allowing both subunits to perform their respective downstream signaling effects. One of the major functions of Gβγ is the inhibition of the Gα subunit.
has abstract
The G beta-gamma complex (Gβγ) ...... inhibition of the Gα subunit.
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23,022,385
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1,021,980,464
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CDD
cd00068
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InterPro
IPR016346
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IPR036284
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name
G-protein, β subunit
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G-protein, γ subunit
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OPM protein
Pfam
PF00631
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PROSITE
PDOC01002
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SMART
GGL
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symbol
G-beta
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G-gamma
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wikiPageUsesTemplate
subject
hypernym
comment
The G beta-gamma complex (Gβγ) ...... inhibition of the Gα subunit.
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label
G beta-gamma complex
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