IDH1
Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which uses NAD+ as the electron acceptor and the other NADP+. Five isocitrate dehydrogenases have been reported: three NAD+-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP+-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP+-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targ
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Acute myeloid leukemiaAgios PharmaceuticalsAzacitidineBAALCBrain tumorDrug nomenclatureGliomaHT1080IDH1 (gene)IDH1 inhibitorIDH3AIDH3BIDH3GIn vivo magnetic resonance spectroscopyIsocitrate dehydrogenaseIvosidenibList of human protein-coding genes 2Maffucci syndromeTet methylcytosine dioxygenase 2The Cancer Genome AtlasTumor metabolomeVictor VelculescuWT1
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IDH1
Isocitrate dehydrogenase 1 (NADP+), soluble is an enzyme that in humans is encoded by the IDH1 gene on chromosome 2. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which uses NAD+ as the electron acceptor and the other NADP+. Five isocitrate dehydrogenases have been reported: three NAD+-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP+-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP+-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP+-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targ
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Isocitrate dehydrogenase 1 (NA ...... [provided by RefSeq, Sep 2013]
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Isocitrate dehydrogenase 1 (NA ...... ins the PTS-1 peroxisomal targ
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IDH1
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