Isocitrate dehydrogenase
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
5-MethylcytosineAlpha-Hydroxyglutaric acidAlpha-Ketoglutaric acidAquifex aeolicusCalcium signalingChondrosarcomaCitric acid cycleDaniel E. Koshland Jr.DehydrogenaseEC 1.1.1.42Essential geneFatty acid metabolismFatty acid synthesisGlioblastomaGliomaIDHIDH1IDH2IDH3AIDH3BIDH3GIdh1Isocitrate/isopropylmalate dehydrogenase familyIsocitrate:NADP+ oxidoreductase (decarboxylating)Isocitrate dehydrogenase (NAD+)Isocitrate dehydrogenase (NADP+)Isocitrate dehydrogenase (NADP+) kinaseIsocitrate lyaseIsocitric acidLeslie D. GottliebList of EC numbers (EC 1)List of MeSH codes (D08)List of enzymesMitochondrial matrixMitochondrionMyelodysplastic syndromeNicotinamide adenine dinucleotide phosphateOxalosuccinic acidOxidative decarboxylationRegulatory enzyme
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Isocitrate dehydrogenase
Isocitrate dehydrogenase (IDH) (EC 1.1.1.42) and (EC 1.1.1.41) is an enzyme that catalyzes the oxidative decarboxylation of isocitrate, producing alpha-ketoglutarate (α-ketoglutarate) and CO2. This is a two-step process, which involves oxidation of isocitrate (a secondary alcohol) to oxalosuccinate (a ketone), followed by the decarboxylation of the carboxyl group beta to the ketone, forming alpha-ketoglutarate. In humans, IDH exists in three isoforms: IDH3 catalyzes the third step of the citric acid cycle while converting NAD+ to NADH in the mitochondria. The isoforms IDH1 and IDH2 catalyze the same reaction outside the context of the citric acid cycle and use NADP+ as a cofactor instead of NAD+. They localize to the cytosol as well as the mitochondrion and peroxisome.
has abstract
(아)이소시트레이트 탈수소효소(IDH,Isocitrat ...... 퍼옥시좀뿐만 아니라 시토졸(cytosol)에 국한된다.
@ko
Isocitrat-Dehydrogenase (IDH) ...... echselstörungen führen können:
@de
Isocitratdehydrogenas är ett e ...... rtkedjan och där generera ATP.
@sv
Isocitrate dehydrogenase (IDH) ...... mitochondrion and peroxisome.
@en
Isocitrato desidrogenase, é um ...... formanto o alfa-cetoglutarato.
@pt
Isocitrátdehydrogenáza (IDH ne ...... ní ionty hořčíku nebo manganu.
@cs
L'isocitrato deidrogenasi (NAD ...... rende parte al ciclo di Krebs.
@it
La enzima Isocitrato deshidrog ...... stá completamente desactivada.
@es
La isocitrat deshidrogenasa (I ...... està completament desactivada.
@ca
L´isocitrate déshydrogénase (I ...... monomérique d' (en) (PDB 1ITW)
@fr
EC number
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Wikipage page ID
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1,019,168,319
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p
@en
q
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band
caption
Crystallographic structure of ...... in the binding site for NADP+.
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crystal structure of the monom ...... complex with isocitrate and mn
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isocitrate dehydrogenase dimer, Human
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CAS number
Chromosome
EC number
ECnumber
EntrezGene
HGNCid
InterPro
IPR004436
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IUBMB EC number
LocusSupplementaryData
-qter
@en
name
Isocitrate dehydrogenase
@en
Monomeric isocitrate dehydrogenase
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isocitrate dehydrogenase 1 , soluble
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isocitrate dehydrogenase 2 , mitochondrial
@en
isocitrate dehydrogenase 3 alpha
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isocitrate dehydrogenase 3 beta
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isocitrate dehydrogenase 3 gamma
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isocitrate dehydrogenase
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OMIM
Pfam
PF03971
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Pfam clan
CL0270
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RefSeq
NM_002168
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NM_005530
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NM_005896
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NM_174855
@en
NM_174869
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symbol
IDH
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IDH1
@en
IDH2
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IDH3A
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IDH3B
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IDH3G
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UniProt
O43837
@en
O75874
@en
P48735
@en
P50213
@en
P51553
@en
wikiPageUsesTemplate
hypernym
comment
(아)이소시트레이트 탈수소효소(IDH,Isocitrat ...... 퍼옥시좀뿐만 아니라 시토졸(cytosol)에 국한된다.
@ko
Isocitrat-Dehydrogenase (IDH) ...... und Ketoglutarat bildet sich.
@de
Isocitratdehydrogenas är ett e ...... rtkedjan och där generera ATP.
@sv
Isocitrate dehydrogenase (IDH) ...... mitochondrion and peroxisome.
@en
Isocitrato desidrogenase, é um ...... formanto o alfa-cetoglutarato.
@pt
Isocitrátdehydrogenáza (IDH ne ...... ní ionty hořčíku nebo manganu.
@cs
L'isocitrato deidrogenasi (NAD ...... rende parte al ciclo di Krebs.
@it
La enzima Isocitrato deshidrog ...... stá completamente desactivada.
@es
La isocitrat deshidrogenasa (I ...... subunitats alfa, beta i gamma.
@ca
L´isocitrate déshydrogénase (I ...... monomérique d' (en) (PDB 1ITW)
@fr
label
Isocitrat deshidrogenasa
@ca
Isocitrat-Dehydrogenase
@de
Isocitratdehydrogenas
@sv
Isocitrate dehydrogenase
@en
Isocitrate déshydrogénase
@fr
Isocitrato deidrogenasi
@it
Isocitrato deshidrogenasa
@es
Isocitrato desidrogenase
@pt
Isocitrátdehydrogenáza
@cs
イソクエン酸デヒドロゲナーゼ
@ja
sameAs
wasDerivedFrom
isPrimaryTopicOf
name
Isocitrate dehydrogenase
@en
isocitrate dehydrogenase (NAD+)
@en