Immunoreceptor tyrosine-based inhibitory motif
An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family found on immune cells. These immune cells include T cells, B cells, NK cells, dendritic cells, macrophages and mast cells. ITIMs have similar structures of S/I/V/LxYxxI/V/L, where x is any amino acid, Y is a tyrosine residue that can be phosphorylated, S is the amino acide Serine, I is the amino acid Isoleucine, and V is the amino acid Valine. ITIMs recruit SH2 domain-containing phosphatases, which inhibit cellular activation. ITIM-containing receptors often serve to target Immunoreceptor tyrosine-based activation motif(ITAM)-containing receptors, r
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CD32CD33CD52CD94/NKG2CLEC12ACentre d'immunologie de Marseille-LuminyFCGR2BFc receptorG protein-coupled receptorITIMImmunological synapseImmunoreceptor tyrosine-based activation motifIndex of immunology articlesKIR2DS1Killer-cell immunoglobulin-like receptorKiller activation receptorKinase tyrosine-based inhibitory motif1,2-dimethoxyethaanLy49MAFANKG2Non-catalytic tyrosine-phosphorylated receptorPILRAProgrammed cell death protein 1SIGLECSIGLEC10SIGLEC8Signal-regulatory protein alphaTIGIT
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Immunoreceptor tyrosine-based inhibitory motif
An immunoreceptor tyrosine-based inhibitory motif (ITIM), is a conserved sequence of amino acids that is found intracellularly in the cytoplasmic domains of many inhibitory receptors of the non-catalytic tyrosine-phosphorylated receptor family found on immune cells. These immune cells include T cells, B cells, NK cells, dendritic cells, macrophages and mast cells. ITIMs have similar structures of S/I/V/LxYxxI/V/L, where x is any amino acid, Y is a tyrosine residue that can be phosphorylated, S is the amino acide Serine, I is the amino acid Isoleucine, and V is the amino acid Valine. ITIMs recruit SH2 domain-containing phosphatases, which inhibit cellular activation. ITIM-containing receptors often serve to target Immunoreceptor tyrosine-based activation motif(ITAM)-containing receptors, r
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An immunoreceptor tyrosine-bas ...... nature S/I/V/LxYxxI/V/L motif.
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An immunoreceptor tyrosine-bas ...... (ITAM)-containing receptors, r
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Immunoreceptor tyrosine-based inhibitory motif
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