Lanosterol 14 alpha-demethylase
Lanosterol 14α-demethylase (CYP51A1) is a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol. The cytochrome P450 isoenzymes are a conserved group of proteins that serve as key players in the metabolism of organic substances and the biosynthesis of important steroids, lipids, and vitamins in eukaryotes. As a member of this family, lanosterol 14α-demethylase is responsible for an essential step in the biosynthesis of sterols. In particular, this protein catalyzes the removal of the C-14α-methyl group from lanosterol. This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell.
14a-demethylaseActive siteAntifungalAzalanstatCYP51A1Cunninghamella elegansCytochrome P450Cytochrome P450 14a-demethylaseCytochrome P450 CYP51 14α-demethylaseEC 1.14.13.70Efinaconazole1,2-dimethoxyethaanFlutrimazoleIsavuconazoniumItraconazoleLanosterol 14-alpha demethylaseLanosterol 14 α-demethylaseLanosterol 14α-demethylaseLevoketoconazoleList of cytochrome P450 modulatorsList of human protein-coding genes 1Oak_wiltPGRMC1PosaconazoleProchlorazPropiconazoleSteroidogenesis inhibitorSterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)SulfacetamideZymoseptoria tritici
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Lanosterol 14 alpha-demethylase
Lanosterol 14α-demethylase (CYP51A1) is a cytochrome P450 enzyme that is involved in the conversion of lanosterol to 4,4-dimethylcholesta-8(9),14,24-trien-3β-ol. The cytochrome P450 isoenzymes are a conserved group of proteins that serve as key players in the metabolism of organic substances and the biosynthesis of important steroids, lipids, and vitamins in eukaryotes. As a member of this family, lanosterol 14α-demethylase is responsible for an essential step in the biosynthesis of sterols. In particular, this protein catalyzes the removal of the C-14α-methyl group from lanosterol. This demethylation step is regarded as the initial checkpoint in the transformation of lanosterol to other sterols that are widely used within the cell.
has abstract
Lanosterol 14α-demethylase (CY ...... e widely used within the cell.
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Wikipage page ID
10,906,045
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Wikipage revision ID
997,548,513
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AltSymbols
CYP51, P45014DM
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Arm
q
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band
Chromosome
ECnumber
EntrezGene
HGNCid
LocusSupplementaryData
name
Cytochrome P450, Family 51, Subfamily A, Polypeptide 1
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OMIM
RefSeq
NM_000786
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symbol
CYP51A1
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UniProt
Q16850
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wikiPageUsesTemplate
comment
Lanosterol 14α-demethylase (CY ...... e widely used within the cell.
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label
Lanosterol 14 alpha-demethylase
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