Low-density lipoprotein receptor-related protein 8
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of specific ligands. Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with certain neurological diseases.
APOER2ApoER2Apoer2Apolipoprotein E Receptor 2Apolipoprotein E receptor 2Cajal–Retzius cellDAB1EGF-like domainLRP8LRP8 (gene)Li-Huei TsaiLipoprotein receptor-related proteinList of human protein-coding genes 2Low-density lipoprotein receptor gene familyLow density lipoprotein receptor-related protein 8Lrp8ReelerReelinSNX17Thrombospondin 1VLDL receptor
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Low-density lipoprotein receptor-related protein 8
Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein that in humans is encoded by the LRP8 gene. ApoER2 is a cell surface receptor that is part of the low-density lipoprotein receptor family. These receptors function in signal transduction and endocytosis of specific ligands. Through interactions with one of its ligands, reelin, ApoER2 plays an important role in embryonic neuronal migration and postnatal long-term potentiation. Another LDL family receptor, VLDLR, also interacts with reelin, and together these two receptors influence brain development and function. Decreased expression of ApoER2 is associated with certain neurological diseases.
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Low-density lipoprotein recept ...... certain neurological diseases.
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Low-density lipoprotein recept ...... certain neurological diseases.
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Low-density lipoprotein receptor-related protein 8
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