Lumacaftor
Lumacaftor (VX-809) is a pharmaceutical drug that acts as a chaperone during protein folding and increases the number of CFTR proteins that are trafficked to the cell surface. It is available in a single pill with ivacaftor; the combination, lumacaftor/ivacaftor (brand name Orkambi), is used to treat people with cystic fibrosis who are homozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the defective protein that causes the disease. It was developed by Vertex Pharmaceuticals and the combination was approved by the FDA in 2015. As of 2015, lumacaftor had no medical use on its own.
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Lumacaftor
Lumacaftor (VX-809) is a pharmaceutical drug that acts as a chaperone during protein folding and increases the number of CFTR proteins that are trafficked to the cell surface. It is available in a single pill with ivacaftor; the combination, lumacaftor/ivacaftor (brand name Orkambi), is used to treat people with cystic fibrosis who are homozygous for the F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the defective protein that causes the disease. It was developed by Vertex Pharmaceuticals and the combination was approved by the FDA in 2015. As of 2015, lumacaftor had no medical use on its own.
has abstract
Le lumacaftor (code du médicam ...... le nom commercial de Orkambi.
@fr
Lumacaftor (VX-809) is a pharm ...... had no medical use on its own.
@en
Lumakaftor (łac. lumacaftorum) ...... -CFTR) na powierzchni komórki.
@pl
ATC code
(combination withivacaftor)
CAS number
936727-05-8
ChEBI
ChEMBL
DrugBank
FDA UNII code
EGP8L81APK
KEGG
PubChem
Wikipage page ID
33,617,496
page length (characters) of wiki page
Wikipage revision ID
973,860,717
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ATC prefix
R07
@en
ATC suffix
AX30
@en
ATC supplemental
@en
CAS number
ChEBI
ChEMBL
ChemSpiderID
17,611,836
DrugBank
DB09280
@en
IUPAC name
IUPHAR ligand
KEGG
D10134
@en
legal US
rx-only
@en
legal US comment
available only as Lumacaftor/ivacaftor
@en
licence EU
yes
@en
PubChem
16,678,941
routes of administration
SMILES
CC1=CC5=CCCO
@en
StdInChIKey
UFSKUSARDNFIRC-UHFFFAOYSA-N
@en
synonyms
VX-809
@en
UNII
EGP8L81APK
@en
Verifiedfields
changed
@en
verifiedrevid
458,773,847
wikiPageUsesTemplate
hypernym
comment
Le lumacaftor (code du médicam ...... le nom commercial de Orkambi.
@fr
Lumacaftor (VX-809) is a pharm ...... had no medical use on its own.
@en
Lumakaftor (łac. lumacaftorum) ...... -CFTR) na powierzchni komórki.
@pl
label
Lumacaftor
@en
Lumacaftor
@fr
Lumakaftor
@pl