The Manskin Indians were a tribe of American Indians who were a part of the Powhatan Confederacy in historic Virginia. From 1620–1750 they are referred to as "Manskin", on several maps, a name derived from Manaskunt. The numerous separate Indian villages shown in the Zuniga Map combined under the rule of Opechancanough, as a result of the pressures of losses from infectious disease and encroachment by the English colonists. The Manskin lived in a two-mile stretch of the Pamunkey River near where today Rt. 360 crosses the Pamunkey River in King William County, Virginia.