Nociceptin receptor
The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. The nociceptin receptor is a member of the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide known as nociceptin (N/OFQ). This receptor is involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. Antagonists targeting NOP are under investigation for their role as treatments for depression and Parkinson's disease, whereas NOP agonists have been shown to act as powerful, non-addictive painkillers in non-human primates.
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AT-076AT-121BTRX-246040BU08028BuprenorphineBuprenorphine-3-glucuronideBuprenorphine/samidorphanCebranopadolEtorphineGi alpha subunitHyperalgesiaJ-113,397JDTicJTC-801LevorphanolList of human protein-coding genes 3List of investigational analgesicsList of investigational antidepressantsList of investigational sleep drugsMCOPPBNNC 63-0532NOPNaloxoneNeurotransmitterNociceptinNorbuprenorphineNorbuprenorphine-3-glucuronideOPRL1OPRL1 (gene)ORL1Opiate receptor-like 1OpioidOpioid antagonistOpioid overdoseOpioid peptideOpioid receptorPain in cephalopodsPain in fishRhodopsin-like receptorsRo64-6198
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Nociceptin receptor
The nociceptin opioid peptide receptor (NOP), also known as the nociceptin/orphanin FQ (N/OFQ) receptor or kappa-type 3 opioid receptor, is a protein that in humans is encoded by the OPRL1 (opioid receptor-like 1) gene. The nociceptin receptor is a member of the opioid subfamily of G protein-coupled receptors whose natural ligand is the 17 amino acid neuropeptide known as nociceptin (N/OFQ). This receptor is involved in the regulation of numerous brain activities, particularly instinctive and emotional behaviors. Antagonists targeting NOP are under investigation for their role as treatments for depression and Parkinson's disease, whereas NOP agonists have been shown to act as powerful, non-addictive painkillers in non-human primates.
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The nociceptin opioid peptide ...... urally related to dynorphin A.
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The nociceptin opioid peptide ...... killers in non-human primates.
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Nociceptin receptor
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